Human GRNs

Cell Type Name Gene Count Regulator Count Target Count Average Targets per TF Average TFs per Target GO Annotations
bcell bcell_subnet_1 911 98 9,484 96.78 10.41 lymphocyte activation (6.42e-156),positive regulation of cell activation (3.84e-104),positive regulation of immune response (4.5e-98),immune response-regulating cell surface receptor signaling pathway (2.99e-97),lymphocyte differentiation (1.03e-80),B cell activation (2.51e-65),leukocyte proliferation (1.41e-64),hemopoietic or lymphoid organ development (6.33e-64),immune effector process (1.31e-62),cytokine production (3.73e-61)
bcell bcell_subnet_2 23 2 25 12.50 1.09
bcell bcell_subnet_3 22 2 27 13.50 1.23
colon colon_subnet_1 480 24 3,028 126.17 6.31 protein O-linked glycosylation (5.38e-38),digestion (3.02e-12),post-translational protein modification (2.85e-09),carbohydrate derivative biosynthetic process (9.62e-08),calcium-independent cell-cell adhesion (1.96e-05),keratinocyte proliferation (0.000275),one-carbon metabolic process (0.0179),excretion (0.0425)
endothelial endothelial_subnet_1 368 20 1,382 69.10 3.76 vasculature development (2.82e-60),endothelial cell migration (9.57e-37),sprouting angiogenesis (6.61e-33),endothelium development (7.3e-33),regulation of locomotion (5.02e-30),endothelial cell proliferation (9.94e-28),vascular endothelial growth factor receptor signaling pathway (8.72e-27),kidney vasculature development (9.37e-23),cell-substrate adhesion (2.58e-18),blood coagulation (1.05e-16)
endothelial endothelial_subnet_2 68 3 107 35.67 1.57 axonogenesis (0.00605)
endothelial endothelial_subnet_3 27 3 39 13.00 1.44
esc esc_subnet_1 907 164 12,896 78.63 14.22 organelle fission (7.02e-167),mitotic prometaphase (5.83e-129),DNA replication (5.63e-122),cell division (4.7e-119),DNA-dependent DNA replication (2.55e-99),interphase (3.63e-97),chromosome segregation (4.33e-93),regulation of cell cycle process (2.96e-92),DNA repair (3.53e-91),DNA strand elongation (2.69e-90)
esc esc_subnet_2 380 42 4,066 96.81 10.70 cell migration involved in gastrulation (6.96e-09),ameboidal cell migration (0.00061),embryonic morphogenesis (0.00209),neural crest cell development (0.00405),neural tube development (0.0121),tube development (0.0305)
fibroblast fibroblast_subnet_1 554 34 3,361 98.85 6.07 extracellular structure organization (4.34e-86),collagen fibril organization (3.98e-69),skeletal system development (7.1e-41),vasculature development (1.55e-37),regulation of locomotion (4.01e-27),tissue morphogenesis (6.29e-27),transmembrane receptor protein serine/threonine kinase signaling pathway (5.51e-26),BMP signaling pathway (1.42e-22),ossification (1.46e-22),Wnt receptor signaling pathway, calcium modulating pathway (9.25e-21)
fibroblast fibroblast_subnet_2 116 5 241 48.20 2.08 regulation of vesicle-mediated transport (0.000807)
fibroblast fibroblast_subnet_3 24 5 32 6.40 1.33 connective tissue development (2.34e-10),skeletal system development (2.48e-07)
heart heart_subnet_1 594 52 4,582 88.12 7.71 muscle system process (2.14e-133),actin filament-based movement (8.6e-106),striated muscle contraction (1.73e-98),muscle structure development (1.38e-94),muscle organ morphogenesis (9.02e-64),heart contraction (1.53e-43),regulation of muscle system process (1.58e-39),cardiac muscle tissue development (1.2e-38),striated muscle cell development (1.32e-37),skeletal muscle tissue development (2.23e-33)
heart heart_subnet_2 34 2 37 18.50 1.09
hspc hspc_subnet_1 907 164 12,896 78.63 14.22 organelle fission (7.02e-167),mitotic prometaphase (5.83e-129),DNA replication (5.63e-122),cell division (4.7e-119),DNA-dependent DNA replication (2.55e-99),interphase (3.63e-97),chromosome segregation (4.33e-93),regulation of cell cycle process (2.96e-92),DNA repair (3.53e-91),DNA strand elongation (2.69e-90)
hspc hspc_subnet_2 221 10 586 58.60 2.65 definitive hemopoiesis (6.67e-28),homeostasis of number of cells (2.2e-27),myeloid cell differentiation (3.94e-22),granulocyte differentiation (1.58e-19),hemopoietic or lymphoid organ development (2.39e-17),megakaryocyte differentiation (6.89e-17),regulation of erythrocyte differentiation (2.16e-16),erythrocyte development (6.51e-16),gas transport (1.61e-14),positive regulation of myeloid cell differentiation (2.01e-11)
kidney kidney_subnet_1 315 12 1,230 102.50 3.90 urate metabolic process (6.92e-32),excretion (2e-24),sodium ion transport (2.93e-15),monovalent inorganic cation transport (1.64e-13),metanephric epithelium development (1.68e-09),anion transport (5.43e-09),organic cation transport (6.27e-09),organic acid transport (2.11e-07),vitamin D metabolic process (4.79e-07),multicellular organismal catabolic process (1.12e-06)
liver liver_subnet_1 607 23 4,490 195.22 7.40 steroid metabolic process (2.75e-91),small molecule catabolic process (5.81e-84),monocarboxylic acid metabolic process (3.63e-75),response to xenobiotic stimulus (1.48e-74),small molecule biosynthetic process (6.21e-68),bile acid metabolic process (8.28e-68),aromatic compound catabolic process (4.83e-64),lipid homeostasis (1.91e-61),protein activation cascade (1.82e-60),drug metabolic process (1.06e-57)
lung lung_subnet_1 181 6 428 71.33 2.36 respiratory gaseous exchange (2.31e-06),lung alveolus development (2.14e-05),tube development (5.85e-05),lung morphogenesis (0.000105),regulation of transforming growth factor beta receptor signaling pathway (0.000366),respiratory system development (0.000505),cell-substrate adhesion (0.000693),transmembrane receptor protein serine/threonine kinase signaling pathway (0.00104),morphogenesis of a branching epithelium (0.0132),cellular response to mechanical stimulus (0.0156)
lung lung_subnet_2 28 3 42 14.00 1.50 purine-containing compound biosynthetic process (2.11e-06),cell-cell adhesion (0.0289)
macrophage macrophage_subnet_1 395 16 1,616 101.00 4.09 inflammatory response (4.63e-66),immune effector process (1.88e-44),interleukin-6 production (6.55e-40),negative regulation of interleukin-12 production (2.52e-39),response to bacterium (1.74e-37),tumor necrosis factor superfamily cytokine production (3.63e-35),leukocyte migration (1.69e-33),cytokine production (1.84e-33),positive regulation of immune response (1.53e-29),defense response to bacterium (4.78e-28)
macrophage macrophage_subnet_2 16 1 15 15.00 0.94 regulation of locomotion (2.98e-05),inflammatory response (0.000159),vasculature development (0.000605)
macrophage macrophage_subnet_3 22 1 21 21.00 0.95
macrophage macrophage_subnet_4 16 1 15 15.00 0.94
muscleSkel muscleSkel_subnet_1 594 52 4,582 88.12 7.71 muscle system process (2.14e-133),actin filament-based movement (8.6e-106),striated muscle contraction (1.73e-98),muscle structure development (1.38e-94),muscle organ morphogenesis (9.02e-64),heart contraction (1.53e-43),regulation of muscle system process (1.58e-39),cardiac muscle tissue development (1.2e-38),striated muscle cell development (1.32e-37),skeletal muscle tissue development (2.23e-33)
neuron neuron_subnet_1 770 46 10,489 228.02 13.62 regulation of neurological system process (1.39e-48),regulation of neurotransmitter levels (2.48e-37),neuron-neuron synaptic transmission (2.36e-35),regulation of membrane potential (9.81e-33),axonogenesis (7.85e-29),regulation of synaptic plasticity (1.12e-26),synaptic vesicle transport (1.28e-26),cognition (2.72e-26),glutamate receptor signaling pathway (7.05e-26),regulation of system process (1.03e-24)
ovary ovary_subnet_1 238 57 1,000 17.54 4.20 protein K11-linked ubiquitination (1.28e-05)
ovary ovary_subnet_2 299 7 578 82.57 1.93 ciliary or flagellar motility (2.24e-48),microtubule-based movement (5.15e-21),cilium movement (3.99e-12),microtubule-based process (3.07e-08),cilium morphogenesis (2.03e-07),cell projection assembly (0.000219),cellular component assembly involved in morphogenesis (0.00082)
ovary ovary_subnet_3 34 1 33 33.00 0.97
skin skin_subnet_1 460 22 3,641 165.50 7.92 epidermis development (8.25e-198),keratinization (1.9e-112),epidermal cell differentiation (1.09e-110),epithelial cell differentiation (2.32e-52),hair cycle (3.9e-27),peptide cross-linking (7.05e-25),skin development (1.86e-12),epidermis morphogenesis (6.61e-12),keratinocyte proliferation (2.4e-08),lateral sprouting from an epithelium (8.5e-07)
tcell tcell_subnet_1 911 98 9,484 96.78 10.41 lymphocyte activation (6.42e-156),positive regulation of cell activation (3.84e-104),positive regulation of immune response (4.5e-98),immune response-regulating cell surface receptor signaling pathway (2.99e-97),lymphocyte differentiation (1.03e-80),B cell activation (2.51e-65),leukocyte proliferation (1.41e-64),hemopoietic or lymphoid organ development (6.33e-64),immune effector process (1.31e-62),cytokine production (3.73e-61)
bcell bcell_subnet_4 475 39 3,065 78.59 6.45 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (4.5e-52),lymphocyte activation (2.74e-36),B cell activation (1.74e-34),immune response-regulating cell surface receptor signaling pathway (1.26e-24),T cell costimulation (2.52e-21),positive regulation of cell activation (1.17e-18),positive regulation of immune response (2.05e-17),humoral immune response (2.41e-15),B cell receptor signaling pathway (1.27e-13),lymphocyte differentiation (1.79e-11)
hspc hspc_subnet_3 567 55 5,708 103.78 10.07 organelle fission (1.12e-203),cell division (1.03e-150),chromosome segregation (4.92e-143),mitotic prometaphase (5.07e-141),regulation of cell cycle process (6.87e-101),DNA replication (3.43e-97),interphase (1.22e-90),sister chromatid segregation (3.27e-80),spindle organization (1.37e-68),DNA-dependent DNA replication (2.47e-67)
hspc hspc_subnet_4 509 56 5,790 103.39 11.38 definitive hemopoiesis (3.95e-05),positive regulation of receptor activity (0.00156),detection of mechanical stimulus (0.00398),negative regulation of myeloid cell differentiation (0.00859),kidney vasculature development (0.0194),regulation of erythrocyte differentiation (0.0255),cellular response to cAMP (0.038),positive regulation of exocytosis (0.0401)
macrophage macrophage_subnet_5 528 54 4,014 74.33 7.60 inflammatory response (3.31e-38),translational initiation (4.88e-28),viral transcription (4.88e-28),establishment of protein localization to organelle (1.53e-22),RNA catabolic process (2.08e-19),cellular component disassembly (2.51e-19),cell chemotaxis (4.23e-11),positive regulation of interleukin-6 production (9.84e-11),acute inflammatory response (1.1e-10),iron ion homeostasis (1.39e-09)
macrophage macrophage_subnet_6 160 10 460 46.00 2.88 platelet degranulation (0.00309),platelet activation (0.0108),protein activation cascade (0.0317)
macrophage macrophage_subnet_7 38 2 44 22.00 1.16
macrophage macrophage_subnet_8 16 3 24 8.00 1.50
tcell tcell_subnet_2 446 23 3,167 137.70 7.10 immune response-regulating cell surface receptor signaling pathway (9.89e-40),lymphocyte activation (5.68e-36),positive regulation of cell activation (1.2e-31),positive regulation of immune response (3.58e-30),lymphocyte differentiation (7.04e-25),regulation of leukocyte mediated cytotoxicity (5.8e-20),T cell costimulation (1.76e-19),alpha-beta T cell activation (2.75e-15),cellular defense response (1.25e-14),response to interleukin-4 (3.67e-12)
colon colon_subnet_2 265 27 1,697 62.85 6.40 protein O-linked glycosylation (9.42e-13),digestion (1.11e-09),carbohydrate derivative biosynthetic process (8.77e-05),cell fate specification (0.0492)
colon colon_subnet_3 195 27 737 27.30 3.78 regulation of epithelial cell differentiation (1.56e-07),protein O-linked glycosylation (3.59e-06),epithelial cell differentiation (1.93e-05),regulation of epidermis development (2.9e-05),body fluid secretion (0.00454),lipid localization (0.0113),monocarboxylic acid transport (0.0329),lipid homeostasis (0.046)
liver liver_subnet_2 114 5 226 45.20 1.98 monocarboxylic acid metabolic process (1.11e-51),protein activation cascade (4.34e-51),steroid metabolic process (8.55e-46),drug metabolic process (4.14e-45),bile acid and bile salt transport (2.92e-40),bile acid metabolic process (4.78e-33),response to xenobiotic stimulus (1.22e-26),serine family amino acid metabolic process (1.15e-23),cellular amino acid metabolic process (7.59e-20),triglyceride homeostasis (1.34e-19)
liver liver_subnet_3 56 5 86 17.20 1.54 protein-lipid complex assembly (2.83e-71),lipid homeostasis (3.31e-50),platelet degranulation (1.85e-36),small molecule catabolic process (3.74e-28),blood coagulation (4.73e-23),cholesterol transport (9.28e-23),platelet activation (4.28e-22),negative regulation of hydrolase activity (7.15e-21),lipoprotein metabolic process (1.57e-20),cellular amino acid biosynthetic process (8.32e-20)
liver liver_subnet_4 28 2 29 14.50 1.04
liver liver_subnet_5 18 4 28 7.00 1.56
liver liver_subnet_6 16 1 15 15.00 0.94
lung lung_subnet_3 140 19 503 26.47 3.59 response to progesterone stimulus (3.42e-21),response to corticosteroid stimulus (6.24e-19),vasculature development (4.45e-16),regulation of vascular endothelial growth factor production (1.53e-14),response to organic cyclic compound (5.99e-14),ovulation (9.07e-14),inflammatory response (1.69e-11),response to mineralocorticoid stimulus (2.99e-11),response to mechanical stimulus (1.56e-10),response to cAMP (3.65e-10)
lung lung_subnet_4 143 10 262 26.20 1.83 chemical homeostasis within a tissue (1.29e-28),ameboidal cell migration (5.06e-06),organ growth (1.6e-05),respiratory gaseous exchange (0.000217),cellular response to mechanical stimulus (0.00043),aminoglycan metabolic process (0.000574),muscle cell proliferation (0.00534),regulation of angiogenesis (0.0157),protein secretion (0.0213)
lung lung_subnet_5 68 9 187 20.78 2.75 regulation of cell morphogenesis (9.53e-06),tube development (5.39e-05),respiratory system development (8.99e-05),limb development (0.00256),negative regulation of locomotion (0.0091)
lung lung_subnet_6 42 6 80 13.33 1.90 collagen fibril organization (3.09e-37),heart morphogenesis (1.38e-16),extracellular structure organization (3.35e-16),cellular response to nutrient (4.39e-15),negative regulation of cell adhesion (1.16e-13),heart development (4.36e-13),epithelial cell differentiation (6.49e-13),skeletal system development (1.41e-12),vasculature development (5.66e-11),response to vitamin (2.33e-10)
lung lung_subnet_7 36 6 46 7.67 1.28
lung lung_subnet_8 28 2 31 15.50 1.11
lung lung_subnet_9 24 6 36 6.00 1.50 vasculature development (0.000275),cell-cell adhesion (0.0033)
lung lung_subnet_10 26 3 32 10.67 1.23
lung lung_subnet_11 19 4 26 6.50 1.37
lung lung_subnet_12 24 2 24 12.00 1.00 response to growth factor stimulus (5.02e-16),connective tissue development (2.32e-10),vasculature development (7.68e-08),regulation of transmembrane transport (1.15e-06),urogenital system development (1.7e-06),positive regulation of transport (3.61e-05),regulation of locomotion (0.0221)
lung lung_subnet_13 20 4 22 5.50 1.10 positive regulation of cell differentiation (0.00567)
lung lung_subnet_14 17 5 23 4.60 1.35
endothelial endothelial_subnet_4 522 49 3,598 73.43 6.89 vasculature development (1.17e-29),kidney vasculature development (7.69e-21),regulation of locomotion (1.01e-20),retina vasculature development in camera-type eye (2.28e-12),nephron development (1.2e-11),urogenital system development (5.2e-11),positive regulation of smooth muscle cell proliferation (7.7e-11),endothelial cell migration (1.05e-10),sprouting angiogenesis (4.64e-10),vascular endothelial growth factor receptor signaling pathway (4.64e-10)
endothelial endothelial_subnet_5 155 8 237 29.63 1.53 organelle fission (1.03e-267),mitotic prometaphase (1.44e-232),cell division (5.9e-184),chromosome segregation (1.88e-168),regulation of cell cycle process (1.09e-147),sister chromatid segregation (4.07e-108),establishment of chromosome localization (2.68e-93),negative regulation of cell cycle (1.33e-86),chromosome condensation (1.62e-83),DNA replication (3.55e-83)
endothelial endothelial_subnet_6 21 6 26 4.33 1.24 protein targeting (0.0196)
fibroblast fibroblast_subnet_4 690 45 5,395 119.89 7.82 extracellular structure organization (7.48e-34),collagen fibril organization (2.35e-25),skeletal system development (1.85e-20),limb development (8.84e-19),vasculature development (8.15e-18),embryonic digit morphogenesis (1.55e-16),tissue morphogenesis (5.95e-16),head development (4.05e-15),heart development (4.4e-14),mesenchyme development (5.71e-13)
heart heart_subnet_3 446 29 2,176 75.03 4.88 cardiac muscle tissue development (1.03e-21),heart contraction (2.12e-15),heart development (2.85e-13),circulatory system process (3.52e-13),cardiac chamber development (1.16e-12),cardiac right ventricle morphogenesis (3.67e-12),muscle system process (1.61e-10),cardiac muscle cell development (2.56e-10),cardioblast differentiation (4.75e-10),cardiac cell differentiation (1.01e-09)
kidney kidney_subnet_2 564 37 4,237 114.51 7.51 excretion (1.41e-23),monocarboxylic acid metabolic process (5.25e-21),anion transport (1.53e-17),urate metabolic process (2.87e-16),small molecule catabolic process (1.75e-14),cellular amino acid metabolic process (2.42e-14),monovalent inorganic cation transport (4.67e-14),cellular aromatic compound metabolic process (4.31e-12),aromatic compound catabolic process (2.53e-11),sodium ion transport (3.32e-11)
muscleSkel muscleSkel_subnet_2 461 54 2,477 45.87 5.37 muscle structure development (8.75e-26),skeletal muscle tissue development (2.52e-22),muscle system process (5.04e-21),actin filament-based movement (1.58e-15),striated muscle contraction (2.02e-08),striated muscle adaptation (5.37e-06),striated muscle cell development (8.34e-06),skeletal system development (0.00158),regulation of ion transport (0.00259),regulation of muscle system process (0.00453)
esc esc_subnet_3 39 11 80 7.27 2.05
esc esc_subnet_4 48 4 48 12.00 1.00
esc esc_subnet_5 25 5 28 5.60 1.12
esc esc_subnet_6 28 1 27 27.00 0.96
ovary ovary_subnet_4 26 2 31 15.50 1.19 epithelial cell proliferation (2.39e-06),vasculature development (0.00114),regulation of defense response (0.0393)
ovary ovary_subnet_5 22 1 21 21.00 0.95
ovary ovary_subnet_6 16 4 20 5.00 1.25
neuron neuron_subnet_2 133 6 181 30.17 1.36 myelination (1.66e-06)
neuron neuron_subnet_3 37 6 67 11.17 1.81 telencephalon development (3.15e-13),second-messenger-mediated signaling (3.88e-08),regulation of cell development (1.92e-07),axonogenesis (0.00132),tube development (0.00809),developmental growth (0.00841),muscle structure development (0.0196),regulation of cell morphogenesis (0.0394)
neuron neuron_subnet_4 22 2 24 12.00 1.09 brain development (0.0192)
skin skin_subnet_2 48 5 61 12.20 1.27 renal system process (8.18e-25),head development (6.04e-21),embryonic skeletal system development (1.36e-16),urogenital system development (5.56e-08),embryo development ending in birth or egg hatching (4.29e-07),cation homeostasis (1.09e-05),circulatory system process (2.31e-05),skeletal system morphogenesis (0.000429),vasculature development (0.000736),anterior/posterior pattern specification (0.00253)

Mouse GRNs

Cell Type Name Gene Count Regulator Count Target Count Average Targets per TF Average TFs per Target GO Annotations
bcell bcell_subnet_1 998 93 13,687 147.17 13.71 lymphocyte activation (8.57e-191),positive regulation of immune system process (1.44e-161),immune response-regulating cell surface receptor signaling pathway (1.05e-120),regulation of T cell activation (5.48e-109),immune effector process (3.72e-103)
bcell bcell_subnet_2 364 46 10,449 227.15 28.71 antigen processing and presentation (6.63e-18),antigen processing and presentation of exogenous antigen (3.5e-17),B cell activation (3.11e-16),B cell receptor signaling pathway (3.31e-14),lymphocyte activation (3.4e-13)
colon colon_subnet_1 862 146 17,069 116.91 19.80 intestinal absorption (3.31e-05),columnar/cuboidal epithelial cell differentiation (0.000102),carbohydrate derivative biosynthetic process (0.000849),nucleotide-sugar metabolic process (0.00351),regulation of hormone levels (0.00637)
colon colon_subnet_2 424 45 4,622 102.71 10.90 keratinocyte proliferation (7.53e-10),interleukin-1 beta secretion (9.37e-06),positive regulation of cytoskeleton organization (0.000561),actin filament bundle assembly (0.00109),carbohydrate derivative biosynthetic process (0.00608)
colon colon_subnet_3 428 64 9,303 145.36 21.74 carbohydrate derivative biosynthetic process (5.04e-12),proximal/distal pattern formation (3.43e-08),oligodendrocyte development (1.46e-05),vesicle localization (0.000331),carbohydrate transmembrane transport (0.000362)
esc esc_subnet_1 928 55 12,546 228.11 13.52 M phase (1.72e-160),DNA replication (1.39e-124),cell division (1.46e-121),chromosome segregation (5.29e-109),DNA-dependent DNA replication (2.06e-86)
esc esc_subnet_2 401 1 34 34.00 0.08 blastocyst formation (5.3e-09),stem cell differentiation (2.18e-08),blastocyst development (2.43e-07),cell fate commitment involved in formation of primary germ layer (0.000338),gastrulation (0.00107)
esc esc_subnet_3 52 8 716 89.50 13.77 neuron fate commitment (2.99e-26),spinal cord development (2.64e-14),cell fate specification (7.07e-12),central nervous system neuron differentiation (1.82e-05),cell fate commitment (3.35e-05)
esc esc_subnet_4 46 7 606 86.57 13.17 tRNA metabolic process (1.82e-07)
esc esc_subnet_5 34 6 287 47.83 8.44
esc esc_subnet_6 33 21 2,156 102.67 65.33
esc esc_subnet_7 33 1 24 24.00 0.73 gastrulation (1.6e-17),mesoderm development (2.13e-15),tissue morphogenesis (2.13e-05),embryonic organ development (3.64e-05),pattern specification process (0.00126)
esc esc_subnet_8 30 14 2,225 158.93 74.17 cellular component biogenesis at cellular level (2.46e-11),ncRNA metabolic process (2.62e-09),cellular amino acid metabolic process (6.84e-07),ATP metabolic process (0.00104),mRNA metabolic process (0.0396)
esc esc_subnet_9 20 20 1,496 74.80 74.80
esc esc_subnet_10 18 7 746 106.57 41.44
esc esc_subnet_11 21 16 1,948 121.75 92.76
fibroblast fibroblast_subnet_1 788 41 5,719 139.49 7.26 collagen fibril organization (2.89e-73),skeletal system development (1.93e-72),blood vessel development (4.65e-66),extracellular structure organization (7.35e-60),ossification (7.17e-57)
fibroblast fibroblast_subnet_2 229 55 12,546 228.11 54.79 M phase (2.83e-240),cell division (1.67e-221),chromosome segregation (9.73e-144),DNA-dependent DNA replication (6.43e-118),DNA replication (1.31e-100)
fibroblast fibroblast_subnet_3 203 18 2,123 117.94 10.46 peptide cross-linking (7.47e-15),positive regulation of cell differentiation (2.18e-12),leukocyte homeostasis (1.23e-10),cell-substrate adhesion (6.66e-10),placenta blood vessel development (1.74e-09)
fibroblast fibroblast_subnet_4 182 13 2,357 181.31 12.95 collagen fibril organization (2.94e-19),skeletal system development (3.97e-18),cartilage condensation (4.13e-15),connective tissue development (1.53e-13),limb development (2.71e-11)
fibroblast fibroblast_subnet_5 106 46 10,449 227.15 98.58 interleukin-6 production (1.5e-16),tumor necrosis factor superfamily cytokine production (2.4e-15),inflammatory response (2.74e-15),I-kappaB kinase/NF-kappaB cascade (1.75e-14),lipopolysaccharide-mediated signaling pathway (5e-12)
fibroblast fibroblast_subnet_6 57 23 4,465 194.13 78.33 axon guidance (3.48e-08),telencephalon development (0.000477),cell morphogenesis involved in differentiation (0.00551),brain development (0.0189)
fibroblast fibroblast_subnet_7 51 93 13,687 147.17 268.37 heart development (0.000836),morphogenesis of a branching epithelium (0.00262)
fibroblast fibroblast_subnet_8 49 42 15,036 358.00 306.86 DNA-dependent transcription, initiation (1.2e-25),mRNA metabolic process (9.66e-24),cellular component biogenesis at cellular level (1.42e-20),RNA splicing, via transesterification reactions (4.64e-19),nucleobase-containing compound transport (1.22e-15)
fibroblast fibroblast_subnet_9 47 18 2,123 117.94 45.17 positive regulation of cell differentiation (0.0257)
fibroblast fibroblast_subnet_10 22 6 134 22.33 6.09 mRNA metabolic process (3.28e-14),cellular component biogenesis at cellular level (4.02e-09)
fibroblast fibroblast_subnet_11 24 2 80 40.00 3.33
fibroblast fibroblast_subnet_12 20 1 25 25.00 1.25
glia glia_subnet_1 921 1 26 26.00 0.03 synaptic transmission (1.49e-119),neurotransmitter transport (7.48e-68),regulation of transmission of nerve impulse (2.14e-47),neuron-neuron synaptic transmission (2.25e-44),glutamate receptor signaling pathway (2.37e-43)
glia glia_subnet_2 35 17 1,922 113.06 54.91
glia glia_subnet_3 83 82 9,436 115.07 113.69 regulation of innate immune response (0.00922)
heart heart_subnet_1 190 64 4,058 63.41 21.36 cardiac ventricle development (3.83e-58),cardiac muscle tissue development (1.22e-55),heart contraction (1.41e-52),striated muscle contraction (2.38e-52),muscle organ morphogenesis (1.92e-51)
heart heart_subnet_2 228 33 4,154 125.88 18.22 electron transport chain (1.45e-244),generation of precursor metabolites and energy (3.47e-168),cellular respiration (3.8e-119),ATP synthesis coupled proton transport (5.3e-107),respiratory electron transport chain (1.12e-85)
heart heart_subnet_3 417 51 4,812 94.35 11.54 heart contraction (7.3e-48),cardiac muscle tissue development (1.29e-44),cardiac ventricle development (1.56e-38),muscle organ morphogenesis (3.04e-38),circulatory system process (1.85e-31)
heart heart_subnet_4 166 29 3,926 135.38 23.65 electron transport chain (4.96e-220),generation of precursor metabolites and energy (2.3e-134),mitochondrial respiratory chain complex assembly (5.59e-100),cellular respiration (3.24e-96),ATP synthesis coupled proton transport (1.48e-85)
hspc hspc_subnet_1 142 30 3,122 104.07 21.99 erythrocyte development (4.05e-14),homeostasis of number of cells (5.39e-10),regulation of erythrocyte differentiation (1.21e-09),myeloid cell differentiation (6.91e-05),regulation of body fluid levels (0.0214)
hspc hspc_subnet_2 608 3 43 14.33 0.07 definitive hemopoiesis (8.65e-15),vasculogenesis (9.18e-07),vascular endothelial growth factor receptor signaling pathway (4.76e-06),embryonic organ development (2.54e-05),embryonic skeletal system development (0.000153)
kidney kidney_subnet_1 422 2 27 13.50 0.06 anion transport (1.02e-32),organic anion transport (6.51e-22),sodium ion transport (2.73e-20),sodium ion transmembrane transport (9.41e-19),urate metabolic process (9.26e-17)
kidney kidney_subnet_2 25 60 5,212 86.87 208.48
kidney kidney_subnet_3 686 5 54 10.80 0.08 sodium ion transport (5.29e-31),anion transport (1.74e-27),monovalent inorganic cation transport (2.36e-21),cellular amino acid metabolic process (1.73e-20),small molecule catabolic process (1.22e-19)
liver liver_subnet_1 416 50 4,275 85.50 10.28 negative regulation of hemostasis (2.79e-48),protein activation cascade (4.92e-43),steroid metabolic process (1.05e-42),sterol metabolic process (3.05e-39),lipid homeostasis (4.94e-38)
liver liver_subnet_2 372 10 395 39.50 1.06 negative regulation of hemostasis (1.26e-54),small molecule catabolic process (4.5e-42),protein activation cascade (1.06e-40),cellular amino acid metabolic process (8.79e-40),aromatic amino acid family metabolic process (8.8e-36)
liver liver_subnet_3 31 25 312 12.48 10.06 cofactor metabolic process (4.86e-05)
liver liver_subnet_4 26 16 269 16.81 10.35 monocarboxylic acid metabolic process (0.00564)
lung lung_subnet_1 259 12 154 12.83 0.59 blood vessel development (1.06e-43),endothelium development (2.06e-29),vascular endothelial growth factor receptor signaling pathway (4.79e-27),vasculogenesis (6.98e-24),vasodilation (4.14e-20)
lung lung_subnet_2 240 1 16 16.00 0.07 cilium movement (1.39e-11),respiratory system development (1.08e-06),lung alveolus development (3.82e-06),positive regulation of heart contraction (7.28e-06),respiratory gaseous exchange (1.12e-05)
lung lung_subnet_3 512 51 4,812 94.35 9.40 blood vessel development (2.81e-31),patterning of blood vessels (1.07e-29),tube development (8.33e-26),tissue morphogenesis (1.26e-25),chemical homeostasis within a tissue (3.84e-21)
lung lung_subnet_4 40 11 965 87.73 24.13 cytokine production (2.84e-09),positive regulation of cell adhesion (9.18e-09),cell-cell adhesion (2e-08),regulation of cell adhesion (6.59e-06),response to growth factor stimulus (1.48e-05)
macrophage macrophage_subnet_1 435 11 67 6.09 0.15 myeloid leukocyte activation (1.07e-46),cytokine production (2.61e-42),positive regulation of immune system process (7.3e-42),inflammatory response (1.61e-40),taxis (5.4e-37)
macrophage macrophage_subnet_2 476 3 46 15.33 0.10 phagocytosis (2.67e-31),positive regulation of phagocytosis (1.49e-29),cytokine production (5.71e-24),endocytosis (9.98e-24),positive regulation of immune system process (3.97e-21)
muscleSkel muscleSkel_subnet_1 640 2 54 27.00 0.08 muscle system process (1.36e-67),striated muscle cell development (4.89e-56),muscle structure development (3.41e-52),striated muscle contraction (7.08e-52),musculoskeletal movement (5.63e-34)
muscleSkel muscleSkel_subnet_2 467 7 42 6.00 0.09 muscle structure development (2.36e-26),muscle system process (1.14e-20),striated muscle contraction (2.95e-14),musculoskeletal movement (3.41e-13),striated muscle cell development (6.79e-11)
muscleSkel muscleSkel_subnet_3 152 9 38 4.22 0.25 actomyosin structure organization (1.77e-52),striated muscle cell development (5.69e-36),cardiac myofibril assembly (2.07e-25),cardiac cell development (1.13e-24),muscle structure development (3.98e-19)
muscleSkel muscleSkel_subnet_4 33 1 29 29.00 0.88
muscleSkel muscleSkel_subnet_5 25 5 24 4.80 0.96
neuron neuron_subnet_1 921 4 20 5.00 0.02 synaptic transmission (1.49e-119),neurotransmitter transport (7.48e-68),regulation of transmission of nerve impulse (2.14e-47),neuron-neuron synaptic transmission (2.25e-44),glutamate receptor signaling pathway (2.37e-43)
neuron neuron_subnet_2 306 2 21 10.50 0.07 synaptic transmission (1.44e-29),neurotransmitter transport (1.1e-15),cell morphogenesis involved in differentiation (1.86e-12),regulation of microtubule polymerization (2.33e-10),axon guidance (2.43e-10)
neuron neuron_subnet_3 137 5 80 16.00 0.58 cerebral cortex neuron differentiation (2.69e-24),synaptic transmission (1.65e-13),telencephalon development (3.67e-09),forebrain generation of neurons (6.09e-08),positive regulation of exocytosis (6.09e-08)
neuron neuron_subnet_4 46 7 25 3.57 0.54 potassium ion transport (4.51e-05),regulation of small GTPase mediated signal transduction (0.00162)
neuron neuron_subnet_5 26 26 1,538 59.15 59.15 synaptic transmission (6.57e-05),positive regulation of hydrolase activity (0.0438)
neuron neuron_subnet_6 22 2 32 16.00 1.45
neuron neuron_subnet_7 19 2 17 8.50 0.89
neuron neuron_subnet_8 16 39 2,056 52.72 128.50
neuron neuron_subnet_9 16 24 581 24.21 36.31
ovary ovary_subnet_1 364 12 577 48.08 1.59 meiotic cell cycle (2.6e-73),male meiosis (1.72e-52),cellular process involved in reproduction (2.98e-46),DNA methylation involved in gamete generation (1.36e-44),chromosome organization involved in meiosis (2.01e-42)
ovary ovary_subnet_2 46 12 244 20.33 5.30 hair cycle (1.38e-11),negative regulation of cell differentiation (0.00132),epidermis development (0.00632)
ovary ovary_subnet_3 24 9 125 13.89 5.21
pancreas pancreas_subnet_1 397 7 82 11.71 0.21 digestion (3.55e-24),pancreas development (4.55e-17),peptide transport (5.44e-15),signal release (1.15e-12),regulation of hormone levels (1.6e-12)
pancreas pancreas_subnet_2 547 12 89 7.42 0.16 signal release (1.14e-22),calcium ion-dependent exocytosis (8.83e-16),synaptic transmission (6.16e-15),peptide transport (8.4e-12),regulation of hormone levels (8.41e-12)
pancreas pancreas_subnet_3 157 5 70 14.00 0.45 response to endoplasmic reticulum stress (4.57e-08),digestion (3.93e-05),response to topologically incorrect protein (0.0234)
pancreas pancreas_subnet_4 103 5 30 6.00 0.29 cytokine metabolic process (0.0124)
pancreas pancreas_subnet_5 90 5 30 6.00 0.33 cilium morphogenesis (1.86e-20),cellular component assembly involved in morphogenesis (6.96e-05),cell projection assembly (0.0498)
pancreas pancreas_subnet_6 68 4 28 7.00 0.41
pancreas pancreas_subnet_7 17 30 3,512 117.07 206.59
si si_subnet_1 862 12 369 30.75 0.43 intestinal absorption (3.31e-05),columnar/cuboidal epithelial cell differentiation (0.000102),carbohydrate derivative biosynthetic process (0.000849),nucleotide-sugar metabolic process (0.00351),regulation of hormone levels (0.00637)
si si_subnet_2 424 49 12,906 263.39 30.44 keratinocyte proliferation (7.53e-10),interleukin-1 beta secretion (9.37e-06),positive regulation of cytoskeleton organization (0.000561),actin filament bundle assembly (0.00109),carbohydrate derivative biosynthetic process (0.00608)
si si_subnet_3 321 45 3,457 76.82 10.77 diacylglycerol metabolic process (1.38e-11),nitrogen compound transport (5.85e-11),organic acid transport (9.19e-11),acylglycerol biosynthetic process (4.17e-08),membrane lipid catabolic process (7.16e-08)
skin skin_subnet_1 499 17 631 37.12 1.26 keratinization (1.26e-81),epidermis development (3.93e-81),epidermal cell differentiation (6.32e-71),hair cycle (3.41e-33),epithelial cell differentiation (1.43e-25)
skin skin_subnet_2 337 5 78 15.60 0.23 epidermis development (1.16e-46),epidermal cell differentiation (5.7e-38),epithelial cell differentiation (1.34e-29),keratinocyte proliferation (7.43e-20),keratinization (6.92e-19)
skin skin_subnet_3 215 1 24 24.00 0.11 muscle system process (2.17e-47),musculoskeletal movement (2.13e-33),striated muscle contraction (1.09e-24),brown fat cell differentiation (1.1e-17),actomyosin structure organization (6.23e-15)
skin skin_subnet_4 64 35 3,333 95.23 52.08 negative regulation of immune system process (4.56e-25),negative regulation of immune response (1.65e-21),negative regulation of T cell activation (3.65e-19),innate immune response (7.76e-17),antigen processing and presentation (8.5e-15)
skin skin_subnet_5 50 7 163 23.29 3.26
tcell tcell_subnet_1 998 35 943 26.94 0.94 lymphocyte activation (8.57e-191),positive regulation of immune system process (1.44e-161),immune response-regulating cell surface receptor signaling pathway (1.05e-120),regulation of T cell activation (5.48e-109),immune effector process (3.72e-103)
tcell tcell_subnet_2 576 9 263 29.22 0.46 lymphocyte activation (2.85e-78),immune response-regulating cell surface receptor signaling pathway (1.32e-71),positive regulation of immune system process (5.27e-66),regulation of T cell activation (1.26e-53),regulation of leukocyte mediated immunity (3.58e-46)
testis testis_subnet_1 1,016 2 45 22.50 0.04 sexual reproduction (8.52e-40),sperm motility (1.14e-18),fertilization (4.64e-10),cellular process involved in reproduction in multicellular organism (5.61e-08),cell-cell recognition (7.96e-08)
testis testis_subnet_2 364 2 25 12.50 0.07 meiotic cell cycle (2.6e-73),male meiosis (1.72e-52),cellular process involved in reproduction (2.98e-46),DNA methylation involved in gamete generation (1.36e-44),chromosome organization involved in meiosis (2.01e-42)
testis testis_subnet_3 431 2 21 10.50 0.05 regulation of lipid metabolic process (1.52e-07),regulation of lipid biosynthetic process (6.87e-07),regulation of lipid catabolic process (0.000598),positive regulation of fatty acid metabolic process (0.000657),cation homeostasis (0.00127)
testis testis_subnet_4 28 3 21 7.00 0.75
testis testis_subnet_5 17 4 17 4.25 1.00
wat wat_subnet_1 67 4 16 4.00 0.24 brown fat cell differentiation (3.77e-123),white fat cell differentiation (1.28e-66),fat cell differentiation (9.36e-48),regulation of triglyceride metabolic process (2.47e-33),neutral lipid metabolic process (9.11e-33)
wat wat_subnet_2 64 44 2,124 48.27 33.19 carbohydrate catabolic process (0.000166),monosaccharide metabolic process (0.0017),innate immune response (0.0157)
wat wat_subnet_3 26 11 706 64.18 27.15
wat wat_subnet_4 27 3 87 29.00 3.22 small molecule catabolic process (6.59e-18),cellular amino acid metabolic process (4.58e-08),lipid catabolic process (3.58e-07),monocarboxylic acid metabolic process (0.00968)
wat wat_subnet_5 569 4 58 14.50 0.10 regulation of lipid metabolic process (1.35e-22),regulation of lipid catabolic process (4e-20),brown fat cell differentiation (3.79e-19),neutral lipid metabolic process (2.26e-17),glycerolipid catabolic process (1.01e-13)