Human GRNs

Cell Type Name Gene Count Regulator Count Target Count Average Targets per TF Average TFs per Target GO Annotations
bcell bcell_subnet_1 911 98 9,484 96.78 10.41 lymphocyte activation (6.42e-156),positive regulation of cell activation (3.84e-104),positive regulation of immune response (4.5e-98),immune response-regulating cell surface receptor signaling pathway (2.99e-97),lymphocyte differentiation (1.03e-80),B cell activation (2.51e-65),leukocyte proliferation (1.41e-64),hemopoietic or lymphoid organ development (6.33e-64),immune effector process (1.31e-62),cytokine production (3.73e-61)
bcell bcell_subnet_2 23 2 25 12.50 1.09
bcell bcell_subnet_3 22 2 27 13.50 1.23
colon colon_subnet_1 480 24 3,028 126.17 6.31 protein O-linked glycosylation (5.38e-38),digestion (3.02e-12),post-translational protein modification (2.85e-09),carbohydrate derivative biosynthetic process (9.62e-08),calcium-independent cell-cell adhesion (1.96e-05),keratinocyte proliferation (0.000275),one-carbon metabolic process (0.0179),excretion (0.0425)
endothelial endothelial_subnet_1 368 20 1,382 69.10 3.76 vasculature development (2.82e-60),endothelial cell migration (9.57e-37),sprouting angiogenesis (6.61e-33),endothelium development (7.3e-33),regulation of locomotion (5.02e-30),endothelial cell proliferation (9.94e-28),vascular endothelial growth factor receptor signaling pathway (8.72e-27),kidney vasculature development (9.37e-23),cell-substrate adhesion (2.58e-18),blood coagulation (1.05e-16)
endothelial endothelial_subnet_2 68 3 107 35.67 1.57 axonogenesis (0.00605)
endothelial endothelial_subnet_3 27 3 39 13.00 1.44
esc esc_subnet_1 907 164 12,896 78.63 14.22 organelle fission (7.02e-167),mitotic prometaphase (5.83e-129),DNA replication (5.63e-122),cell division (4.7e-119),DNA-dependent DNA replication (2.55e-99),interphase (3.63e-97),chromosome segregation (4.33e-93),regulation of cell cycle process (2.96e-92),DNA repair (3.53e-91),DNA strand elongation (2.69e-90)
esc esc_subnet_2 380 42 4,066 96.81 10.70 cell migration involved in gastrulation (6.96e-09),ameboidal cell migration (0.00061),embryonic morphogenesis (0.00209),neural crest cell development (0.00405),neural tube development (0.0121),tube development (0.0305)
fibroblast fibroblast_subnet_1 554 34 3,361 98.85 6.07 extracellular structure organization (4.34e-86),collagen fibril organization (3.98e-69),skeletal system development (7.1e-41),vasculature development (1.55e-37),regulation of locomotion (4.01e-27),tissue morphogenesis (6.29e-27),transmembrane receptor protein serine/threonine kinase signaling pathway (5.51e-26),BMP signaling pathway (1.42e-22),ossification (1.46e-22),Wnt receptor signaling pathway, calcium modulating pathway (9.25e-21)
fibroblast fibroblast_subnet_2 116 5 241 48.20 2.08 regulation of vesicle-mediated transport (0.000807)
fibroblast fibroblast_subnet_3 24 5 32 6.40 1.33 connective tissue development (2.34e-10),skeletal system development (2.48e-07)
heart heart_subnet_1 594 52 4,582 88.12 7.71 muscle system process (2.14e-133),actin filament-based movement (8.6e-106),striated muscle contraction (1.73e-98),muscle structure development (1.38e-94),muscle organ morphogenesis (9.02e-64),heart contraction (1.53e-43),regulation of muscle system process (1.58e-39),cardiac muscle tissue development (1.2e-38),striated muscle cell development (1.32e-37),skeletal muscle tissue development (2.23e-33)
heart heart_subnet_2 34 2 37 18.50 1.09
hspc hspc_subnet_1 907 164 12,896 78.63 14.22 organelle fission (7.02e-167),mitotic prometaphase (5.83e-129),DNA replication (5.63e-122),cell division (4.7e-119),DNA-dependent DNA replication (2.55e-99),interphase (3.63e-97),chromosome segregation (4.33e-93),regulation of cell cycle process (2.96e-92),DNA repair (3.53e-91),DNA strand elongation (2.69e-90)
hspc hspc_subnet_2 221 10 586 58.60 2.65 definitive hemopoiesis (6.67e-28),homeostasis of number of cells (2.2e-27),myeloid cell differentiation (3.94e-22),granulocyte differentiation (1.58e-19),hemopoietic or lymphoid organ development (2.39e-17),megakaryocyte differentiation (6.89e-17),regulation of erythrocyte differentiation (2.16e-16),erythrocyte development (6.51e-16),gas transport (1.61e-14),positive regulation of myeloid cell differentiation (2.01e-11)
kidney kidney_subnet_1 315 12 1,230 102.50 3.90 urate metabolic process (6.92e-32),excretion (2e-24),sodium ion transport (2.93e-15),monovalent inorganic cation transport (1.64e-13),metanephric epithelium development (1.68e-09),anion transport (5.43e-09),organic cation transport (6.27e-09),organic acid transport (2.11e-07),vitamin D metabolic process (4.79e-07),multicellular organismal catabolic process (1.12e-06)
liver liver_subnet_1 607 23 4,490 195.22 7.40 steroid metabolic process (2.75e-91),small molecule catabolic process (5.81e-84),monocarboxylic acid metabolic process (3.63e-75),response to xenobiotic stimulus (1.48e-74),small molecule biosynthetic process (6.21e-68),bile acid metabolic process (8.28e-68),aromatic compound catabolic process (4.83e-64),lipid homeostasis (1.91e-61),protein activation cascade (1.82e-60),drug metabolic process (1.06e-57)
lung lung_subnet_1 181 6 428 71.33 2.36 respiratory gaseous exchange (2.31e-06),lung alveolus development (2.14e-05),tube development (5.85e-05),lung morphogenesis (0.000105),regulation of transforming growth factor beta receptor signaling pathway (0.000366),respiratory system development (0.000505),cell-substrate adhesion (0.000693),transmembrane receptor protein serine/threonine kinase signaling pathway (0.00104),morphogenesis of a branching epithelium (0.0132),cellular response to mechanical stimulus (0.0156)
lung lung_subnet_2 28 3 42 14.00 1.50 purine-containing compound biosynthetic process (2.11e-06),cell-cell adhesion (0.0289)
macrophage macrophage_subnet_1 395 16 1,616 101.00 4.09 inflammatory response (4.63e-66),immune effector process (1.88e-44),interleukin-6 production (6.55e-40),negative regulation of interleukin-12 production (2.52e-39),response to bacterium (1.74e-37),tumor necrosis factor superfamily cytokine production (3.63e-35),leukocyte migration (1.69e-33),cytokine production (1.84e-33),positive regulation of immune response (1.53e-29),defense response to bacterium (4.78e-28)
macrophage macrophage_subnet_2 16 1 15 15.00 0.94 regulation of locomotion (2.98e-05),inflammatory response (0.000159),vasculature development (0.000605)
macrophage macrophage_subnet_3 22 1 21 21.00 0.95
macrophage macrophage_subnet_4 16 1 15 15.00 0.94
muscleSkel muscleSkel_subnet_1 594 52 4,582 88.12 7.71 muscle system process (2.14e-133),actin filament-based movement (8.6e-106),striated muscle contraction (1.73e-98),muscle structure development (1.38e-94),muscle organ morphogenesis (9.02e-64),heart contraction (1.53e-43),regulation of muscle system process (1.58e-39),cardiac muscle tissue development (1.2e-38),striated muscle cell development (1.32e-37),skeletal muscle tissue development (2.23e-33)
neuron neuron_subnet_1 770 46 10,489 228.02 13.62 regulation of neurological system process (1.39e-48),regulation of neurotransmitter levels (2.48e-37),neuron-neuron synaptic transmission (2.36e-35),regulation of membrane potential (9.81e-33),axonogenesis (7.85e-29),regulation of synaptic plasticity (1.12e-26),synaptic vesicle transport (1.28e-26),cognition (2.72e-26),glutamate receptor signaling pathway (7.05e-26),regulation of system process (1.03e-24)
ovary ovary_subnet_1 238 57 1,000 17.54 4.20 protein K11-linked ubiquitination (1.28e-05)
ovary ovary_subnet_2 299 7 578 82.57 1.93 ciliary or flagellar motility (2.24e-48),microtubule-based movement (5.15e-21),cilium movement (3.99e-12),microtubule-based process (3.07e-08),cilium morphogenesis (2.03e-07),cell projection assembly (0.000219),cellular component assembly involved in morphogenesis (0.00082)
ovary ovary_subnet_3 34 1 33 33.00 0.97
skin skin_subnet_1 460 22 3,641 165.50 7.92 epidermis development (8.25e-198),keratinization (1.9e-112),epidermal cell differentiation (1.09e-110),epithelial cell differentiation (2.32e-52),hair cycle (3.9e-27),peptide cross-linking (7.05e-25),skin development (1.86e-12),epidermis morphogenesis (6.61e-12),keratinocyte proliferation (2.4e-08),lateral sprouting from an epithelium (8.5e-07)
tcell tcell_subnet_1 911 98 9,484 96.78 10.41 lymphocyte activation (6.42e-156),positive regulation of cell activation (3.84e-104),positive regulation of immune response (4.5e-98),immune response-regulating cell surface receptor signaling pathway (2.99e-97),lymphocyte differentiation (1.03e-80),B cell activation (2.51e-65),leukocyte proliferation (1.41e-64),hemopoietic or lymphoid organ development (6.33e-64),immune effector process (1.31e-62),cytokine production (3.73e-61)
bcell bcell_subnet_4 475 39 3,065 78.59 6.45 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (4.5e-52),lymphocyte activation (2.74e-36),B cell activation (1.74e-34),immune response-regulating cell surface receptor signaling pathway (1.26e-24),T cell costimulation (2.52e-21),positive regulation of cell activation (1.17e-18),positive regulation of immune response (2.05e-17),humoral immune response (2.41e-15),B cell receptor signaling pathway (1.27e-13),lymphocyte differentiation (1.79e-11)
hspc hspc_subnet_3 567 55 5,708 103.78 10.07 organelle fission (1.12e-203),cell division (1.03e-150),chromosome segregation (4.92e-143),mitotic prometaphase (5.07e-141),regulation of cell cycle process (6.87e-101),DNA replication (3.43e-97),interphase (1.22e-90),sister chromatid segregation (3.27e-80),spindle organization (1.37e-68),DNA-dependent DNA replication (2.47e-67)
hspc hspc_subnet_4 509 56 5,790 103.39 11.38 definitive hemopoiesis (3.95e-05),positive regulation of receptor activity (0.00156),detection of mechanical stimulus (0.00398),negative regulation of myeloid cell differentiation (0.00859),kidney vasculature development (0.0194),regulation of erythrocyte differentiation (0.0255),cellular response to cAMP (0.038),positive regulation of exocytosis (0.0401)
macrophage macrophage_subnet_5 528 54 4,014 74.33 7.60 inflammatory response (3.31e-38),translational initiation (4.88e-28),viral transcription (4.88e-28),establishment of protein localization to organelle (1.53e-22),RNA catabolic process (2.08e-19),cellular component disassembly (2.51e-19),cell chemotaxis (4.23e-11),positive regulation of interleukin-6 production (9.84e-11),acute inflammatory response (1.1e-10),iron ion homeostasis (1.39e-09)
macrophage macrophage_subnet_6 160 10 460 46.00 2.88 platelet degranulation (0.00309),platelet activation (0.0108),protein activation cascade (0.0317)
macrophage macrophage_subnet_7 38 2 44 22.00 1.16
macrophage macrophage_subnet_8 16 3 24 8.00 1.50
tcell tcell_subnet_2 446 23 3,167 137.70 7.10 immune response-regulating cell surface receptor signaling pathway (9.89e-40),lymphocyte activation (5.68e-36),positive regulation of cell activation (1.2e-31),positive regulation of immune response (3.58e-30),lymphocyte differentiation (7.04e-25),regulation of leukocyte mediated cytotoxicity (5.8e-20),T cell costimulation (1.76e-19),alpha-beta T cell activation (2.75e-15),cellular defense response (1.25e-14),response to interleukin-4 (3.67e-12)
colon colon_subnet_2 265 27 1,697 62.85 6.40 protein O-linked glycosylation (9.42e-13),digestion (1.11e-09),carbohydrate derivative biosynthetic process (8.77e-05),cell fate specification (0.0492)
colon colon_subnet_3 195 27 737 27.30 3.78 regulation of epithelial cell differentiation (1.56e-07),protein O-linked glycosylation (3.59e-06),epithelial cell differentiation (1.93e-05),regulation of epidermis development (2.9e-05),body fluid secretion (0.00454),lipid localization (0.0113),monocarboxylic acid transport (0.0329),lipid homeostasis (0.046)
liver liver_subnet_2 114 5 226 45.20 1.98 monocarboxylic acid metabolic process (1.11e-51),protein activation cascade (4.34e-51),steroid metabolic process (8.55e-46),drug metabolic process (4.14e-45),bile acid and bile salt transport (2.92e-40),bile acid metabolic process (4.78e-33),response to xenobiotic stimulus (1.22e-26),serine family amino acid metabolic process (1.15e-23),cellular amino acid metabolic process (7.59e-20),triglyceride homeostasis (1.34e-19)
liver liver_subnet_3 56 5 86 17.20 1.54 protein-lipid complex assembly (2.83e-71),lipid homeostasis (3.31e-50),platelet degranulation (1.85e-36),small molecule catabolic process (3.74e-28),blood coagulation (4.73e-23),cholesterol transport (9.28e-23),platelet activation (4.28e-22),negative regulation of hydrolase activity (7.15e-21),lipoprotein metabolic process (1.57e-20),cellular amino acid biosynthetic process (8.32e-20)
liver liver_subnet_4 28 2 29 14.50 1.04
liver liver_subnet_5 18 4 28 7.00 1.56
liver liver_subnet_6 16 1 15 15.00 0.94
lung lung_subnet_3 140 19 503 26.47 3.59 response to progesterone stimulus (3.42e-21),response to corticosteroid stimulus (6.24e-19),vasculature development (4.45e-16),regulation of vascular endothelial growth factor production (1.53e-14),response to organic cyclic compound (5.99e-14),ovulation (9.07e-14),inflammatory response (1.69e-11),response to mineralocorticoid stimulus (2.99e-11),response to mechanical stimulus (1.56e-10),response to cAMP (3.65e-10)
lung lung_subnet_4 143 10 262 26.20 1.83 chemical homeostasis within a tissue (1.29e-28),ameboidal cell migration (5.06e-06),organ growth (1.6e-05),respiratory gaseous exchange (0.000217),cellular response to mechanical stimulus (0.00043),aminoglycan metabolic process (0.000574),muscle cell proliferation (0.00534),regulation of angiogenesis (0.0157),protein secretion (0.0213)
lung lung_subnet_5 68 9 187 20.78 2.75 regulation of cell morphogenesis (9.53e-06),tube development (5.39e-05),respiratory system development (8.99e-05),limb development (0.00256),negative regulation of locomotion (0.0091)
lung lung_subnet_6 42 6 80 13.33 1.90 collagen fibril organization (3.09e-37),heart morphogenesis (1.38e-16),extracellular structure organization (3.35e-16),cellular response to nutrient (4.39e-15),negative regulation of cell adhesion (1.16e-13),heart development (4.36e-13),epithelial cell differentiation (6.49e-13),skeletal system development (1.41e-12),vasculature development (5.66e-11),response to vitamin (2.33e-10)
lung lung_subnet_7 36 6 46 7.67 1.28
lung lung_subnet_8 28 2 31 15.50 1.11
lung lung_subnet_9 24 6 36 6.00 1.50 vasculature development (0.000275),cell-cell adhesion (0.0033)
lung lung_subnet_10 26 3 32 10.67 1.23
lung lung_subnet_11 19 4 26 6.50 1.37
lung lung_subnet_12 24 2 24 12.00 1.00 response to growth factor stimulus (5.02e-16),connective tissue development (2.32e-10),vasculature development (7.68e-08),regulation of transmembrane transport (1.15e-06),urogenital system development (1.7e-06),positive regulation of transport (3.61e-05),regulation of locomotion (0.0221)
lung lung_subnet_13 20 4 22 5.50 1.10 positive regulation of cell differentiation (0.00567)
lung lung_subnet_14 17 5 23 4.60 1.35
endothelial endothelial_subnet_4 522 49 3,598 73.43 6.89 vasculature development (1.17e-29),kidney vasculature development (7.69e-21),regulation of locomotion (1.01e-20),retina vasculature development in camera-type eye (2.28e-12),nephron development (1.2e-11),urogenital system development (5.2e-11),positive regulation of smooth muscle cell proliferation (7.7e-11),endothelial cell migration (1.05e-10),sprouting angiogenesis (4.64e-10),vascular endothelial growth factor receptor signaling pathway (4.64e-10)
endothelial endothelial_subnet_5 155 8 237 29.63 1.53 organelle fission (1.03e-267),mitotic prometaphase (1.44e-232),cell division (5.9e-184),chromosome segregation (1.88e-168),regulation of cell cycle process (1.09e-147),sister chromatid segregation (4.07e-108),establishment of chromosome localization (2.68e-93),negative regulation of cell cycle (1.33e-86),chromosome condensation (1.62e-83),DNA replication (3.55e-83)
endothelial endothelial_subnet_6 21 6 26 4.33 1.24 protein targeting (0.0196)
fibroblast fibroblast_subnet_4 690 45 5,395 119.89 7.82 extracellular structure organization (7.48e-34),collagen fibril organization (2.35e-25),skeletal system development (1.85e-20),limb development (8.84e-19),vasculature development (8.15e-18),embryonic digit morphogenesis (1.55e-16),tissue morphogenesis (5.95e-16),head development (4.05e-15),heart development (4.4e-14),mesenchyme development (5.71e-13)
heart heart_subnet_3 446 29 2,176 75.03 4.88 cardiac muscle tissue development (1.03e-21),heart contraction (2.12e-15),heart development (2.85e-13),circulatory system process (3.52e-13),cardiac chamber development (1.16e-12),cardiac right ventricle morphogenesis (3.67e-12),muscle system process (1.61e-10),cardiac muscle cell development (2.56e-10),cardioblast differentiation (4.75e-10),cardiac cell differentiation (1.01e-09)
kidney kidney_subnet_2 564 37 4,237 114.51 7.51 excretion (1.41e-23),monocarboxylic acid metabolic process (5.25e-21),anion transport (1.53e-17),urate metabolic process (2.87e-16),small molecule catabolic process (1.75e-14),cellular amino acid metabolic process (2.42e-14),monovalent inorganic cation transport (4.67e-14),cellular aromatic compound metabolic process (4.31e-12),aromatic compound catabolic process (2.53e-11),sodium ion transport (3.32e-11)
muscleSkel muscleSkel_subnet_2 461 54 2,477 45.87 5.37 muscle structure development (8.75e-26),skeletal muscle tissue development (2.52e-22),muscle system process (5.04e-21),actin filament-based movement (1.58e-15),striated muscle contraction (2.02e-08),striated muscle adaptation (5.37e-06),striated muscle cell development (8.34e-06),skeletal system development (0.00158),regulation of ion transport (0.00259),regulation of muscle system process (0.00453)
esc esc_subnet_3 39 11 80 7.27 2.05
esc esc_subnet_4 48 4 48 12.00 1.00
esc esc_subnet_5 25 5 28 5.60 1.12
esc esc_subnet_6 28 1 27 27.00 0.96
ovary ovary_subnet_4 26 2 31 15.50 1.19 epithelial cell proliferation (2.39e-06),vasculature development (0.00114),regulation of defense response (0.0393)
ovary ovary_subnet_5 22 1 21 21.00 0.95
ovary ovary_subnet_6 16 4 20 5.00 1.25
neuron neuron_subnet_2 133 6 181 30.17 1.36 myelination (1.66e-06)
neuron neuron_subnet_3 37 6 67 11.17 1.81 telencephalon development (3.15e-13),second-messenger-mediated signaling (3.88e-08),regulation of cell development (1.92e-07),axonogenesis (0.00132),tube development (0.00809),developmental growth (0.00841),muscle structure development (0.0196),regulation of cell morphogenesis (0.0394)
neuron neuron_subnet_4 22 2 24 12.00 1.09 brain development (0.0192)
skin skin_subnet_2 48 5 61 12.20 1.27 renal system process (8.18e-25),head development (6.04e-21),embryonic skeletal system development (1.36e-16),urogenital system development (5.56e-08),embryo development ending in birth or egg hatching (4.29e-07),cation homeostasis (1.09e-05),circulatory system process (2.31e-05),skeletal system morphogenesis (0.000429),vasculature development (0.000736),anterior/posterior pattern specification (0.00253)