Mouse GRNs

Cell Type Name Gene Count Regulator Count Target Count Average Targets per TF Average TFs per Target GO Annotations
bcell bcell_subnet_1 998 93 13,687 147.17 13.71 lymphocyte activation (8.57e-191),positive regulation of immune system process (1.44e-161),immune response-regulating cell surface receptor signaling pathway (1.05e-120),regulation of T cell activation (5.48e-109),immune effector process (3.72e-103)
bcell bcell_subnet_2 364 46 10,449 227.15 28.71 antigen processing and presentation (6.63e-18),antigen processing and presentation of exogenous antigen (3.5e-17),B cell activation (3.11e-16),B cell receptor signaling pathway (3.31e-14),lymphocyte activation (3.4e-13)
colon colon_subnet_1 862 146 17,069 116.91 19.80 intestinal absorption (3.31e-05),columnar/cuboidal epithelial cell differentiation (0.000102),carbohydrate derivative biosynthetic process (0.000849),nucleotide-sugar metabolic process (0.00351),regulation of hormone levels (0.00637)
colon colon_subnet_2 424 45 4,622 102.71 10.90 keratinocyte proliferation (7.53e-10),interleukin-1 beta secretion (9.37e-06),positive regulation of cytoskeleton organization (0.000561),actin filament bundle assembly (0.00109),carbohydrate derivative biosynthetic process (0.00608)
colon colon_subnet_3 428 64 9,303 145.36 21.74 carbohydrate derivative biosynthetic process (5.04e-12),proximal/distal pattern formation (3.43e-08),oligodendrocyte development (1.46e-05),vesicle localization (0.000331),carbohydrate transmembrane transport (0.000362)
esc esc_subnet_1 928 55 12,546 228.11 13.52 M phase (1.72e-160),DNA replication (1.39e-124),cell division (1.46e-121),chromosome segregation (5.29e-109),DNA-dependent DNA replication (2.06e-86)
esc esc_subnet_2 401 1 34 34.00 0.08 blastocyst formation (5.3e-09),stem cell differentiation (2.18e-08),blastocyst development (2.43e-07),cell fate commitment involved in formation of primary germ layer (0.000338),gastrulation (0.00107)
esc esc_subnet_3 52 8 716 89.50 13.77 neuron fate commitment (2.99e-26),spinal cord development (2.64e-14),cell fate specification (7.07e-12),central nervous system neuron differentiation (1.82e-05),cell fate commitment (3.35e-05)
esc esc_subnet_4 46 7 606 86.57 13.17 tRNA metabolic process (1.82e-07)
esc esc_subnet_5 34 6 287 47.83 8.44
esc esc_subnet_6 33 21 2,156 102.67 65.33
esc esc_subnet_7 33 1 24 24.00 0.73 gastrulation (1.6e-17),mesoderm development (2.13e-15),tissue morphogenesis (2.13e-05),embryonic organ development (3.64e-05),pattern specification process (0.00126)
esc esc_subnet_8 30 14 2,225 158.93 74.17 cellular component biogenesis at cellular level (2.46e-11),ncRNA metabolic process (2.62e-09),cellular amino acid metabolic process (6.84e-07),ATP metabolic process (0.00104),mRNA metabolic process (0.0396)
esc esc_subnet_9 20 20 1,496 74.80 74.80
esc esc_subnet_10 18 7 746 106.57 41.44
esc esc_subnet_11 21 16 1,948 121.75 92.76
fibroblast fibroblast_subnet_1 788 41 5,719 139.49 7.26 collagen fibril organization (2.89e-73),skeletal system development (1.93e-72),blood vessel development (4.65e-66),extracellular structure organization (7.35e-60),ossification (7.17e-57)
fibroblast fibroblast_subnet_2 229 55 12,546 228.11 54.79 M phase (2.83e-240),cell division (1.67e-221),chromosome segregation (9.73e-144),DNA-dependent DNA replication (6.43e-118),DNA replication (1.31e-100)
fibroblast fibroblast_subnet_3 203 18 2,123 117.94 10.46 peptide cross-linking (7.47e-15),positive regulation of cell differentiation (2.18e-12),leukocyte homeostasis (1.23e-10),cell-substrate adhesion (6.66e-10),placenta blood vessel development (1.74e-09)
fibroblast fibroblast_subnet_4 182 13 2,357 181.31 12.95 collagen fibril organization (2.94e-19),skeletal system development (3.97e-18),cartilage condensation (4.13e-15),connective tissue development (1.53e-13),limb development (2.71e-11)
fibroblast fibroblast_subnet_5 106 46 10,449 227.15 98.58 interleukin-6 production (1.5e-16),tumor necrosis factor superfamily cytokine production (2.4e-15),inflammatory response (2.74e-15),I-kappaB kinase/NF-kappaB cascade (1.75e-14),lipopolysaccharide-mediated signaling pathway (5e-12)
fibroblast fibroblast_subnet_6 57 23 4,465 194.13 78.33 axon guidance (3.48e-08),telencephalon development (0.000477),cell morphogenesis involved in differentiation (0.00551),brain development (0.0189)
fibroblast fibroblast_subnet_7 51 93 13,687 147.17 268.37 heart development (0.000836),morphogenesis of a branching epithelium (0.00262)
fibroblast fibroblast_subnet_8 49 42 15,036 358.00 306.86 DNA-dependent transcription, initiation (1.2e-25),mRNA metabolic process (9.66e-24),cellular component biogenesis at cellular level (1.42e-20),RNA splicing, via transesterification reactions (4.64e-19),nucleobase-containing compound transport (1.22e-15)
fibroblast fibroblast_subnet_9 47 18 2,123 117.94 45.17 positive regulation of cell differentiation (0.0257)
fibroblast fibroblast_subnet_10 22 6 134 22.33 6.09 mRNA metabolic process (3.28e-14),cellular component biogenesis at cellular level (4.02e-09)
fibroblast fibroblast_subnet_11 24 2 80 40.00 3.33
fibroblast fibroblast_subnet_12 20 1 25 25.00 1.25
glia glia_subnet_1 921 1 26 26.00 0.03 synaptic transmission (1.49e-119),neurotransmitter transport (7.48e-68),regulation of transmission of nerve impulse (2.14e-47),neuron-neuron synaptic transmission (2.25e-44),glutamate receptor signaling pathway (2.37e-43)
glia glia_subnet_2 35 17 1,922 113.06 54.91
glia glia_subnet_3 83 82 9,436 115.07 113.69 regulation of innate immune response (0.00922)
heart heart_subnet_1 190 64 4,058 63.41 21.36 cardiac ventricle development (3.83e-58),cardiac muscle tissue development (1.22e-55),heart contraction (1.41e-52),striated muscle contraction (2.38e-52),muscle organ morphogenesis (1.92e-51)
heart heart_subnet_2 228 33 4,154 125.88 18.22 electron transport chain (1.45e-244),generation of precursor metabolites and energy (3.47e-168),cellular respiration (3.8e-119),ATP synthesis coupled proton transport (5.3e-107),respiratory electron transport chain (1.12e-85)
heart heart_subnet_3 417 51 4,812 94.35 11.54 heart contraction (7.3e-48),cardiac muscle tissue development (1.29e-44),cardiac ventricle development (1.56e-38),muscle organ morphogenesis (3.04e-38),circulatory system process (1.85e-31)
heart heart_subnet_4 166 29 3,926 135.38 23.65 electron transport chain (4.96e-220),generation of precursor metabolites and energy (2.3e-134),mitochondrial respiratory chain complex assembly (5.59e-100),cellular respiration (3.24e-96),ATP synthesis coupled proton transport (1.48e-85)
hspc hspc_subnet_1 142 30 3,122 104.07 21.99 erythrocyte development (4.05e-14),homeostasis of number of cells (5.39e-10),regulation of erythrocyte differentiation (1.21e-09),myeloid cell differentiation (6.91e-05),regulation of body fluid levels (0.0214)
hspc hspc_subnet_2 608 3 43 14.33 0.07 definitive hemopoiesis (8.65e-15),vasculogenesis (9.18e-07),vascular endothelial growth factor receptor signaling pathway (4.76e-06),embryonic organ development (2.54e-05),embryonic skeletal system development (0.000153)
kidney kidney_subnet_1 422 2 27 13.50 0.06 anion transport (1.02e-32),organic anion transport (6.51e-22),sodium ion transport (2.73e-20),sodium ion transmembrane transport (9.41e-19),urate metabolic process (9.26e-17)
kidney kidney_subnet_2 25 60 5,212 86.87 208.48
kidney kidney_subnet_3 686 5 54 10.80 0.08 sodium ion transport (5.29e-31),anion transport (1.74e-27),monovalent inorganic cation transport (2.36e-21),cellular amino acid metabolic process (1.73e-20),small molecule catabolic process (1.22e-19)
liver liver_subnet_1 416 50 4,275 85.50 10.28 negative regulation of hemostasis (2.79e-48),protein activation cascade (4.92e-43),steroid metabolic process (1.05e-42),sterol metabolic process (3.05e-39),lipid homeostasis (4.94e-38)
liver liver_subnet_2 372 10 395 39.50 1.06 negative regulation of hemostasis (1.26e-54),small molecule catabolic process (4.5e-42),protein activation cascade (1.06e-40),cellular amino acid metabolic process (8.79e-40),aromatic amino acid family metabolic process (8.8e-36)
liver liver_subnet_3 31 25 312 12.48 10.06 cofactor metabolic process (4.86e-05)
liver liver_subnet_4 26 16 269 16.81 10.35 monocarboxylic acid metabolic process (0.00564)
lung lung_subnet_1 259 12 154 12.83 0.59 blood vessel development (1.06e-43),endothelium development (2.06e-29),vascular endothelial growth factor receptor signaling pathway (4.79e-27),vasculogenesis (6.98e-24),vasodilation (4.14e-20)
lung lung_subnet_2 240 1 16 16.00 0.07 cilium movement (1.39e-11),respiratory system development (1.08e-06),lung alveolus development (3.82e-06),positive regulation of heart contraction (7.28e-06),respiratory gaseous exchange (1.12e-05)
lung lung_subnet_3 512 51 4,812 94.35 9.40 blood vessel development (2.81e-31),patterning of blood vessels (1.07e-29),tube development (8.33e-26),tissue morphogenesis (1.26e-25),chemical homeostasis within a tissue (3.84e-21)
lung lung_subnet_4 40 11 965 87.73 24.13 cytokine production (2.84e-09),positive regulation of cell adhesion (9.18e-09),cell-cell adhesion (2e-08),regulation of cell adhesion (6.59e-06),response to growth factor stimulus (1.48e-05)
macrophage macrophage_subnet_1 435 11 67 6.09 0.15 myeloid leukocyte activation (1.07e-46),cytokine production (2.61e-42),positive regulation of immune system process (7.3e-42),inflammatory response (1.61e-40),taxis (5.4e-37)
macrophage macrophage_subnet_2 476 3 46 15.33 0.10 phagocytosis (2.67e-31),positive regulation of phagocytosis (1.49e-29),cytokine production (5.71e-24),endocytosis (9.98e-24),positive regulation of immune system process (3.97e-21)
muscleSkel muscleSkel_subnet_1 640 2 54 27.00 0.08 muscle system process (1.36e-67),striated muscle cell development (4.89e-56),muscle structure development (3.41e-52),striated muscle contraction (7.08e-52),musculoskeletal movement (5.63e-34)
muscleSkel muscleSkel_subnet_2 467 7 42 6.00 0.09 muscle structure development (2.36e-26),muscle system process (1.14e-20),striated muscle contraction (2.95e-14),musculoskeletal movement (3.41e-13),striated muscle cell development (6.79e-11)
muscleSkel muscleSkel_subnet_3 152 9 38 4.22 0.25 actomyosin structure organization (1.77e-52),striated muscle cell development (5.69e-36),cardiac myofibril assembly (2.07e-25),cardiac cell development (1.13e-24),muscle structure development (3.98e-19)
muscleSkel muscleSkel_subnet_4 33 1 29 29.00 0.88
muscleSkel muscleSkel_subnet_5 25 5 24 4.80 0.96
neuron neuron_subnet_1 921 4 20 5.00 0.02 synaptic transmission (1.49e-119),neurotransmitter transport (7.48e-68),regulation of transmission of nerve impulse (2.14e-47),neuron-neuron synaptic transmission (2.25e-44),glutamate receptor signaling pathway (2.37e-43)
neuron neuron_subnet_2 306 2 21 10.50 0.07 synaptic transmission (1.44e-29),neurotransmitter transport (1.1e-15),cell morphogenesis involved in differentiation (1.86e-12),regulation of microtubule polymerization (2.33e-10),axon guidance (2.43e-10)
neuron neuron_subnet_3 137 5 80 16.00 0.58 cerebral cortex neuron differentiation (2.69e-24),synaptic transmission (1.65e-13),telencephalon development (3.67e-09),forebrain generation of neurons (6.09e-08),positive regulation of exocytosis (6.09e-08)
neuron neuron_subnet_4 46 7 25 3.57 0.54 potassium ion transport (4.51e-05),regulation of small GTPase mediated signal transduction (0.00162)
neuron neuron_subnet_5 26 26 1,538 59.15 59.15 synaptic transmission (6.57e-05),positive regulation of hydrolase activity (0.0438)
neuron neuron_subnet_6 22 2 32 16.00 1.45
neuron neuron_subnet_7 19 2 17 8.50 0.89
neuron neuron_subnet_8 16 39 2,056 52.72 128.50
neuron neuron_subnet_9 16 24 581 24.21 36.31
ovary ovary_subnet_1 364 12 577 48.08 1.59 meiotic cell cycle (2.6e-73),male meiosis (1.72e-52),cellular process involved in reproduction (2.98e-46),DNA methylation involved in gamete generation (1.36e-44),chromosome organization involved in meiosis (2.01e-42)
ovary ovary_subnet_2 46 12 244 20.33 5.30 hair cycle (1.38e-11),negative regulation of cell differentiation (0.00132),epidermis development (0.00632)
ovary ovary_subnet_3 24 9 125 13.89 5.21
pancreas pancreas_subnet_1 397 7 82 11.71 0.21 digestion (3.55e-24),pancreas development (4.55e-17),peptide transport (5.44e-15),signal release (1.15e-12),regulation of hormone levels (1.6e-12)
pancreas pancreas_subnet_2 547 12 89 7.42 0.16 signal release (1.14e-22),calcium ion-dependent exocytosis (8.83e-16),synaptic transmission (6.16e-15),peptide transport (8.4e-12),regulation of hormone levels (8.41e-12)
pancreas pancreas_subnet_3 157 5 70 14.00 0.45 response to endoplasmic reticulum stress (4.57e-08),digestion (3.93e-05),response to topologically incorrect protein (0.0234)
pancreas pancreas_subnet_4 103 5 30 6.00 0.29 cytokine metabolic process (0.0124)
pancreas pancreas_subnet_5 90 5 30 6.00 0.33 cilium morphogenesis (1.86e-20),cellular component assembly involved in morphogenesis (6.96e-05),cell projection assembly (0.0498)
pancreas pancreas_subnet_6 68 4 28 7.00 0.41
pancreas pancreas_subnet_7 17 30 3,512 117.07 206.59
si si_subnet_1 862 12 369 30.75 0.43 intestinal absorption (3.31e-05),columnar/cuboidal epithelial cell differentiation (0.000102),carbohydrate derivative biosynthetic process (0.000849),nucleotide-sugar metabolic process (0.00351),regulation of hormone levels (0.00637)
si si_subnet_2 424 49 12,906 263.39 30.44 keratinocyte proliferation (7.53e-10),interleukin-1 beta secretion (9.37e-06),positive regulation of cytoskeleton organization (0.000561),actin filament bundle assembly (0.00109),carbohydrate derivative biosynthetic process (0.00608)
si si_subnet_3 321 45 3,457 76.82 10.77 diacylglycerol metabolic process (1.38e-11),nitrogen compound transport (5.85e-11),organic acid transport (9.19e-11),acylglycerol biosynthetic process (4.17e-08),membrane lipid catabolic process (7.16e-08)
skin skin_subnet_1 499 17 631 37.12 1.26 keratinization (1.26e-81),epidermis development (3.93e-81),epidermal cell differentiation (6.32e-71),hair cycle (3.41e-33),epithelial cell differentiation (1.43e-25)
skin skin_subnet_2 337 5 78 15.60 0.23 epidermis development (1.16e-46),epidermal cell differentiation (5.7e-38),epithelial cell differentiation (1.34e-29),keratinocyte proliferation (7.43e-20),keratinization (6.92e-19)
skin skin_subnet_3 215 1 24 24.00 0.11 muscle system process (2.17e-47),musculoskeletal movement (2.13e-33),striated muscle contraction (1.09e-24),brown fat cell differentiation (1.1e-17),actomyosin structure organization (6.23e-15)
skin skin_subnet_4 64 35 3,333 95.23 52.08 negative regulation of immune system process (4.56e-25),negative regulation of immune response (1.65e-21),negative regulation of T cell activation (3.65e-19),innate immune response (7.76e-17),antigen processing and presentation (8.5e-15)
skin skin_subnet_5 50 7 163 23.29 3.26
tcell tcell_subnet_1 998 35 943 26.94 0.94 lymphocyte activation (8.57e-191),positive regulation of immune system process (1.44e-161),immune response-regulating cell surface receptor signaling pathway (1.05e-120),regulation of T cell activation (5.48e-109),immune effector process (3.72e-103)
tcell tcell_subnet_2 576 9 263 29.22 0.46 lymphocyte activation (2.85e-78),immune response-regulating cell surface receptor signaling pathway (1.32e-71),positive regulation of immune system process (5.27e-66),regulation of T cell activation (1.26e-53),regulation of leukocyte mediated immunity (3.58e-46)
testis testis_subnet_1 1,016 2 45 22.50 0.04 sexual reproduction (8.52e-40),sperm motility (1.14e-18),fertilization (4.64e-10),cellular process involved in reproduction in multicellular organism (5.61e-08),cell-cell recognition (7.96e-08)
testis testis_subnet_2 364 2 25 12.50 0.07 meiotic cell cycle (2.6e-73),male meiosis (1.72e-52),cellular process involved in reproduction (2.98e-46),DNA methylation involved in gamete generation (1.36e-44),chromosome organization involved in meiosis (2.01e-42)
testis testis_subnet_3 431 2 21 10.50 0.05 regulation of lipid metabolic process (1.52e-07),regulation of lipid biosynthetic process (6.87e-07),regulation of lipid catabolic process (0.000598),positive regulation of fatty acid metabolic process (0.000657),cation homeostasis (0.00127)
testis testis_subnet_4 28 3 21 7.00 0.75
testis testis_subnet_5 17 4 17 4.25 1.00
wat wat_subnet_1 67 4 16 4.00 0.24 brown fat cell differentiation (3.77e-123),white fat cell differentiation (1.28e-66),fat cell differentiation (9.36e-48),regulation of triglyceride metabolic process (2.47e-33),neutral lipid metabolic process (9.11e-33)
wat wat_subnet_2 64 44 2,124 48.27 33.19 carbohydrate catabolic process (0.000166),monosaccharide metabolic process (0.0017),innate immune response (0.0157)
wat wat_subnet_3 26 11 706 64.18 27.15
wat wat_subnet_4 27 3 87 29.00 3.22 small molecule catabolic process (6.59e-18),cellular amino acid metabolic process (4.58e-08),lipid catabolic process (3.58e-07),monocarboxylic acid metabolic process (0.00968)
wat wat_subnet_5 569 4 58 14.50 0.10 regulation of lipid metabolic process (1.35e-22),regulation of lipid catabolic process (4e-20),brown fat cell differentiation (3.79e-19),neutral lipid metabolic process (2.26e-17),glycerolipid catabolic process (1.01e-13)