Gene Regulatory Network

Homo Sapiens: lung_subnet_1

Gene Count Regulator Count Target Count Average Targets per TF Average TFs per Target
181 6 428 30.00 0.03

Top GO Annotations

respiratory gaseous exchange (2.31e-06), lung alveolus development (2.14e-05), tube development (5.85e-05), lung morphogenesis (0.000105), regulation of transforming growth factor beta receptor signaling pathway (0.000366), respiratory system development (0.000505), cell-substrate adhesion (0.000693), transmembrane receptor protein serine/threonine kinase signaling pathway (0.00104), morphogenesis of a branching epithelium (0.0132), cellular response to mechanical stimulus (0.0156)

Tissue Types







GRN Members

TG TF Z-Score Correlation Tissue Type
SFTA3 NKX2-1 51.53 0.95 all
CLDN18 NKX2-1 43.44 0.91 all
SFTPC NKX2-1 39.42 0.88 all
SFTPB NKX2-1 36.95 0.87 all
SFTA2 NKX2-1 37.83 0.87 all
SFTPA2 NKX2-1 29.79 0.82 all
AGER NKX2-1 27.09 0.80 all
FLJ35700 TCF21 11.24 0.79 all
SCGB1A1 NKX2-1 26.62 0.79 all
NDNF TCF21 10.42 0.77 all
PLA2G1B NKX2-1 24.32 0.77 all
SFTPD NKX2-1 24.05 0.77 all
ROS1 NKX2-1 23.45 0.76 all
SCGB3A2 NKX2-1 22.25 0.75 all
MS4A15 NKX2-1 20.94 0.74 all
GDF10 NKX2-1 21.56 0.74 all
SLC34A2 NKX2-1 21.60 0.74 all
C7 TCF21 9.61 0.74 all
CCDC68 TCF21 9.28 0.73 all
PGC NKX2-1 20.10 0.73 all
KCNK3 NKX2-1 18.98 0.71 all
GPRC5A FOXF1 8.92 0.71 all
SLC6A4 NKX2-1 18.16 0.70 all
SFTA1P NKX2-1 17.38 0.69 all
BMP5 TCF21 8.03 0.69 all
CXCL17 NKX2-1 17.59 0.69 all
EDNRA TCF21 7.85 0.68 all
NAPSA NKX2-1 16.15 0.67 all
C16orf89 NKX2-1 15.95 0.67 all
SCGB3A1 NKX2-1 15.81 0.67 all
GKN2 NKX2-1 15.17 0.66 all
FIGF NKX2-1 15.11 0.66 all
NOSTRIN TCF21 7.20 0.66 all
ITGA8 TCF21 7.30 0.66 all
COL6A6 NKX2-1 15.11 0.66 all
TMEM100 TCF21 7.32 0.66 all
LAMP3 NKX2-1 15.29 0.66 all
ITGA8 TBX2 10.31 0.65 all
WIF1 NKX2-1 14.56 0.65 all
ADAMTS8 NKX2-1 14.83 0.65 all
BMP5 FOXF1 7.37 0.65 all
NPNT TCF21 6.98 0.65 all
TBX2 NKX2-1 13.69 0.64 all
SLCO2A1 TCF21 6.86 0.64 all
TCF21 TBX2 9.86 0.64 all
CACNA2D2 NKX2-1 13.64 0.63 all
PLEKHH2 TCF21 6.55 0.63 all
OGN TCF21 6.66 0.63 all
C1QTNF7 TCF21 6.62 0.63 all
CNTN6 NKX2-1 12.53 0.62 all
SFTA3 TCF21 6.35 0.62 all
BMP5 NKX2-1 12.67 0.62 all
ITGA1 TCF21 6.30 0.62 all
GPRC5A TCF21 6.15 0.61 all
SFTA3 TBX2 8.94 0.61 all
SCN7A TCF21 6.19 0.61 all
C16orf89 TBX2 9.07 0.61 all
CHIA NKX2-1 11.89 0.60 all
AGTR2 NKX2-1 11.59 0.60 all
SFTA2 TBX2 8.66 0.60 all
C16orf89 TCF21 5.94 0.60 all
TCF21 FOXF1 6.22 0.60 all
CYP4B1 NKX2-1 11.98 0.60 all
RARRES1 TCF21 5.98 0.60 all
INMT TBX2 8.48 0.60 all
NDNF TBX2 8.40 0.59 all
ADH1B TCF21 5.85 0.59 all
SLC6A14 NKX2-1 11.15 0.59 all
RERG TCF21 5.88 0.59 all
NAPSA TBX2 8.36 0.59 all
EGFL6 NKX2-1 11.41 0.59 all
CCDC102B NKX2-1 11.33 0.59 all
CLEC3B TBX2 8.33 0.59 all
TRPC6 NKX2-1 10.91 0.58 all
CCDC68 FOXF1 5.76 0.58 all
SUSD2 NKX2-1 10.89 0.58 all
CCDC102B FOXF1 5.76 0.58 all
ABCA3 NKX2-1 10.72 0.58 all
EDNRA TBX2 7.98 0.58 all
CPAMD8 TBX4 7.70 0.58 all
NDNF NKX2-1 10.96 0.58 all
INMT TCF21 5.59 0.58 all
SFTPB TBX2 7.78 0.57 all
C8orf4 TCF21 5.43 0.57 all
NCKAP5 FOXF1 5.60 0.57 all
LGALS3BP TCF21 5.41 0.57 all
SFTPB TCF21 5.51 0.57 all
C11orf96 EGR1 9.36 0.57 all
PLEKHH2 NKX2-1 10.52 0.57 all
SLC34A2 TBX2 7.70 0.57 all
CLDN18 TBX2 7.86 0.57 all
AOC3 TCF21 5.47 0.57 all
AQP4 NKX2-1 10.31 0.57 all
SLC34A2 TCF21 5.40 0.57 all
SUSD2 TBX2 7.69 0.57 all
TCF21 NKX2-1 10.21 0.57 all
CCDC102B TCF21 5.51 0.57 all
SPON1 TCF21 5.38 0.57 all
SFTPC TBX2 7.82 0.57 all
SFTA3 FOXF1 5.55 0.57 all
COL6A5 NKX2-1 9.84 0.56 all
MSLN NKX2-1 10.10 0.56 all
FOXF1 NKX2-1 9.95 0.56 all
C11orf96 TCF21 5.20 0.56 all
PLA2G1B TCF21 5.24 0.56 all
PRDM6 TBX4 7.30 0.56 all
HIGD1B TBX4 7.23 0.56 all
RTKN2 NKX2-1 9.45 0.55 all
MAGI3 FOXF1 5.29 0.55 all
FCN3 TCF21 5.16 0.55 all
RAMP3 TCF21 5.04 0.55 all
TMTC2 FOXF1 5.17 0.55 all
CTSE FOXF1 5.15 0.55 all
NAPSA TCF21 5.17 0.55 all
SFTA2 TCF21 5.07 0.55 all
FAM162B TCF21 5.02 0.55 all
INMT NKX2-1 9.56 0.55 all
SFTPA2 TCF21 5.03 0.55 all
ITGA8 NKX2-1 9.00 0.54 all
SFTPC TCF21 4.94 0.54 all
TBX4 NKX2-1 9.19 0.54 all
NEDD9 TCF21 4.91 0.54 all
GJA5 NKX2-1 9.25 0.54 all
FLJ35700 FOXF1 5.06 0.54 all
FOXF1 TBX2 6.78 0.54 all
AQP1 TCF21 4.97 0.54 all
CLDN18 TCF21 4.91 0.54 all
EDNRA NKX2-1 9.25 0.54 all
FAM162B NKX2-1 9.01 0.54 all
ITGA1 FOXF1 5.01 0.54 all
CPAMD8 NKX2-1 8.97 0.54 all
DENND2A TCF21 4.94 0.54 all
FMO2 NKX2-1 9.28 0.54 all
SCN7A NKX2-1 9.26 0.54 all
SFTPC TBX4 6.70 0.54 all
FMO2 TCF21 4.69 0.53 all
FCN3 TBX2 6.66 0.53 all
CEBPD TCF21 4.83 0.53 all
TMEM100 NKX2-1 8.74 0.53 all
NCKAP5 NKX2-1 8.79 0.53 all
FLJ35700 TBX2 6.57 0.53 all
SPON1 FOXF1 4.94 0.53 all
GRP NKX2-1 8.73 0.53 all
RARRES1 FOXF1 4.98 0.53 all
CXCL17 TBX2 6.68 0.53 all
FMO2 TBX2 6.55 0.53 all
ADAMTSL3 TCF21 4.76 0.53 all
CLIC6 TCF21 4.63 0.52 all
FIGF TBX2 6.30 0.52 all
PLEKHH2 FOXF1 4.72 0.52 all
CLDN18 FOXF1 4.77 0.52 all
FHL5 NKX2-1 8.27 0.52 all
SUSD2 TCF21 4.68 0.52 all
CCDC102B TBX2 6.37 0.52 all
FAM162B TBX2 6.40 0.52 all
CLEC3B TCF21 4.61 0.52 all
SCGB1A1 TCF21 4.51 0.51 all
SCN7A TBX2 6.13 0.51 all
C8orf4 FOXF1 4.63 0.51 all
CEBPD EGR1 7.27 0.51 all
TRPC6 TBX2 6.06 0.51 all
SFTA3 TBX4 5.98 0.51 all
TMEM100 FOXF1 4.53 0.51 all
COL6A6 TCF21 4.42 0.51 all
NPNT FOXF1 4.53 0.51 all
GJA5 TCF21 4.43 0.51 all
AOC3 NKX2-1 8.06 0.51 all
NCKAP5 TCF21 4.48 0.51 all
FLJ35700 NKX2-1 8.03 0.51 all
CPAMD8 TBX2 6.23 0.51 all
FIGF TBX4 5.98 0.51 all
SCGB1A1 TBX2 6.21 0.51 all
NOSTRIN FOXF1 4.59 0.51 all
SCGB3A1 TBX2 6.13 0.51 all
KCNJ8 TCF21 4.27 0.50 all
TBX4 TBX2 5.95 0.50 all
LYVE1 TCF21 4.33 0.50 all
CEBPD TBX2 5.89 0.50 all
FOLR1 TBX2 5.89 0.50 all
C11orf96 FOXF1 4.49 0.50 all
IL33 FOXF1 4.38 0.50 all
CTSE TCF21 4.35 0.50 all
PLEKHH2 TBX2 5.91 0.50 all
PLA2G1B FOXF1 4.40 0.50 all
BMP5 TBX2 5.96 0.50 all
C11orf96 TBX2 5.82 0.50 all
SFTPA2 FOXF1 4.39 0.50 all
LOC100128750 TBX2 5.94 0.50 all
WFDC1 FOXF1 4.39 0.50 all
KCNK3 TBX4 5.67 0.50 all
NKX2-1-AS1 NKX2-1 7.79 0.50 all
NEDD9 FOXF1 4.43 0.50 all
GPIHBP1 TBX4 5.60 0.49 all
MAGI3 TCF21 4.26 0.49 all
CEBPD FOXF1 4.36 0.49 all
FCN3 NKX2-1 7.33 0.49 all
LEPREL1 TCF21 4.17 0.49 all
LPCAT1 NKX2-1 7.36 0.49 all
FLRT3 TCF21 4.12 0.49 all
C20orf85 NKX2-1 7.45 0.49 all
C7 TBX2 5.59 0.49 all
WNT2 NKX2-1 7.24 0.49 all
WNT2 TBX2 5.60 0.49 all
SFTPA2 TBX2 5.73 0.49 all
SFTPD TCF21 4.19 0.49 all
CEBPD NKX2-1 7.18 0.48 all
TMEM100 EGR1 6.37 0.48 all
SFTA2 FOXF1 4.12 0.48 all
SFTPB TBX4 5.43 0.48 all
RAMP3 TBX2 5.56 0.48 all
GDF10 TBX2 5.46 0.48 all
DMBT1 TCF21 4.02 0.48 all
SLC6A4 TBX2 5.50 0.48 all
LTBP4 TBX2 5.42 0.48 all
AOC3 TBX2 5.49 0.48 all
AQP1 TBX2 5.47 0.48 all
PGC TBX2 5.49 0.48 all
PLA2G1B TBX2 5.59 0.48 all
DENND2A FOXF1 4.20 0.48 all
BPIFB1 NKX2-1 7.20 0.48 all
AGER TBX2 5.55 0.48 all
ROS1 TBX2 5.45 0.48 all
ITGA1 TBX2 5.42 0.48 all
MYH11 TCF21 4.00 0.48 all
FAM110D TBX4 5.38 0.48 all
CH25H FOXF1 4.11 0.48 all
TRPC6 FOXF1 4.11 0.48 all
GEM TCF21 4.10 0.48 all
LMO7 TBX2 5.32 0.47 all
GDF10 TBX4 5.07 0.47 all
C1QTNF7 NKX2-1 6.90 0.47 all
PRDM6 NKX2-1 6.65 0.47 all
SLCO2A1 TBX2 5.25 0.47 all
GEM EGR1 6.04 0.47 all
CLIC6 TBX2 5.12 0.46 all
NEDD9 TBX2 5.02 0.46 all
STEAP4 NKX2-1 6.38 0.46 all
NOSTRIN TBX2 5.09 0.46 all
KANK2 TBX2 5.04 0.46 all
C8orf4 TBX2 5.00 0.46 all
MS4A15 TBX2 5.05 0.46 all
FOLR1 NKX2-1 6.53 0.46 all
DMBT1 NKX2-1 6.35 0.46 all
MSLN TBX2 5.13 0.46 all
GJA5 TBX2 5.09 0.46 all
CTSE NKX2-1 6.56 0.46 all
NPNT NKX2-1 6.35 0.46 all
LTBP4 TBX4 4.92 0.46 all
EDNRA EGR1 5.73 0.46 all
SLC26A9 NKX2-1 6.61 0.46 all
SLC26A9 TBX2 5.12 0.46 all
GPRC5A NKX2-1 6.51 0.46 all
ZNF385B NKX2-1 6.46 0.46 all
NEDD9 NKX2-1 6.54 0.46 all
COL6A6 TBX2 4.93 0.45 all
MTMR9LP TBX4 4.84 0.45 all
C11orf96 NKX2-1 6.17 0.45 all
CLDN18 TBX4 4.82 0.45 all
C20orf85 TBX2 4.90 0.45 all
KCNK3 TBX2 4.96 0.45 all
CAPSL TBX2 4.85 0.45 all
REM1 TBX4 4.83 0.45 all
HIGD1B NKX2-1 6.14 0.45 all
GPIHBP1 NKX2-1 6.13 0.45 all
ADAMTSL3 TBX2 4.90 0.45 all
ARHGEF26 EGR1 5.55 0.45 all
FOXF1-AS1 TBX4 4.78 0.45 all
FMO2 TBX4 4.51 0.44 all
LYVE1 NKX2-1 5.87 0.44 all
RERG EGR1 5.40 0.44 all
CDKN1C TBX2 4.64 0.44 all
ATP11A NKX2-1 6.00 0.44 all
LGALS3BP TBX2 4.76 0.44 all
CSF3 TBX4 4.65 0.44 all
ALDH3B1 TBX2 4.72 0.44 all
SLC34A2 EGR1 5.27 0.44 all
NCKAP5 TBX2 4.78 0.44 all
GRK5 TBX4 4.52 0.44 all
C7 EGR1 5.27 0.44 all
CCDC102B EGR1 5.27 0.44 all
SLCO2A1 NKX2-1 5.87 0.44 all
MYH11 TBX2 4.66 0.44 all
WFDC1 TBX2 4.76 0.44 all
PRDM6 TBX2 4.69 0.44 all
CYP4B1 TBX2 4.70 0.44 all
GEM TBX2 4.77 0.44 all
ADH1B TBX2 4.75 0.44 all
STEAP4 EGR1 5.30 0.44 all
GPR97 TBX4 4.38 0.43 all
IGSF10 NKX2-1 5.76 0.43 all
ITGA8 TBX4 4.34 0.43 all
NCKAP5 EGR1 5.08 0.43 all
ITGB6 TBX2 4.61 0.43 all
ACADL TBX2 4.61 0.43 all
PLEKHH2 EGR1 5.11 0.43 all
MS4A2 NKX2-1 5.67 0.43 all
ACOXL NKX2-1 5.81 0.43 all
NAPSA TBX4 4.36 0.43 all
IL33 EGR1 5.20 0.43 all
IL33 NKX2-1 5.78 0.43 all
NPNT TBX2 4.55 0.43 all
SCGB3A2 TBX4 4.40 0.43 all
PGC TBX4 4.47 0.43 all
C1QTNF7 TBX2 4.55 0.43 all
INMT EGR1 5.19 0.43 all
CLEC3B NKX2-1 5.74 0.43 all
ROS1 TBX4 4.37 0.43 all
SFTPD TBX2 4.56 0.43 all
CLIC6 NKX2-1 5.72 0.43 all
KCNJ8 TBX2 4.32 0.42 all
OR7E47P TBX2 4.44 0.42 all
FAM167B TBX2 4.46 0.42 all
COL6A6 EGR1 4.95 0.42 all
FAM216B NKX2-1 5.37 0.42 all
NPNT EGR1 4.85 0.42 all
FAM216B TBX2 4.43 0.42 all
SFTA2 TBX4 4.23 0.42 all
GYPC TBX4 4.30 0.42 all
CCDC68 TBX2 4.31 0.42 all
GPC3 NKX2-1 5.58 0.42 all
COX4I2 TBX4 4.31 0.42 all
PHYHD1 TBX2 4.37 0.42 all
SEMA3B TBX2 4.34 0.42 all
TPPP3 NKX2-1 5.57 0.42 all
TPPP3 TBX2 4.21 0.41 all
SFTA1P TBX2 4.29 0.41 all
ADAMTS8 TBX2 4.17 0.41 all
ODAM NKX2-1 5.33 0.41 all
FAM189A2 TBX4 4.10 0.41 all
AOC3 EGR1 4.71 0.41 all
TMEM100 TBX2 4.19 0.41 all
OGN EGR1 4.75 0.41 all
DARC NKX2-1 5.32 0.41 all
STK40 TBX4 4.08 0.41 all
CASKIN2 NKX2-1 5.34 0.41 all
C1QTNF7 EGR1 4.77 0.41 all
GPR20 TBX2 4.26 0.41 all
SCGB3A2 TBX2 4.25 0.41 all
CASKIN2 TBX2 4.28 0.41 all
GPR20 TBX4 4.07 0.41 all
SFTPD EGR1 4.75 0.41 all
AGER TBX4 4.03 0.41 all
WNT2 TBX4 4.13 0.41 all
RXFP1 NKX2-1 5.17 0.41 all
HERC2P3 NKX2-1 5.20 0.41 all
SCN7A EGR1 4.74 0.41 all
FOXF1-AS1 NKX2-1 5.21 0.41 all
GPIHBP1 TBX2 4.14 0.41 all
ARHGEF26 NKX2-1 5.26 0.41 all
SMAD6 TBX2 4.11 0.40 all
FCN3 EGR1 4.58 0.40 all
STEAP4 TBX2 4.07 0.40 all
GKN2 TBX2 4.00 0.40 all
RERG TBX2 4.01 0.40 all
RGCC NKX2-1 5.01 0.40 all
NKD2 NKX2-1 4.91 0.40 all
FHL5 TBX2 4.04 0.40 all
OGN TBX2 4.01 0.40 all
DENND2A TBX2 4.11 0.40 all
NOSTRIN EGR1 4.57 0.40 all
ADH1B EGR1 4.60 0.40 all
C8orf4 EGR1 4.57 0.40 all
GPRC5A TBX2 4.10 0.40 all
ANGPT1 TBX2 4.03 0.40 all
KCNJ8 EGR1 4.27 0.39 all
ITGB6 NKX2-1 4.84 0.39 all
SFTA2 EGR1 4.26 0.39 all
SLC6A14 EGR1 4.36 0.39 all
RAMP3 NKX2-1 4.90 0.39 all
TLE2 NKX2-1 4.77 0.39 all
LTBP4 NKX2-1 4.74 0.39 all
DARC EGR1 4.32 0.39 all
CCDC68 NKX2-1 4.87 0.39 all
PLA2G1B EGR1 4.29 0.39 all
COX4I2 NKX2-1 4.84 0.39 all
LOC100128750 NKX2-1 4.82 0.39 all
SFTA3 EGR1 4.29 0.39 all
ANGPT1 NKX2-1 4.83 0.39 all
SYDE2 NKX2-1 4.70 0.38 all
GPR97 NKX2-1 4.62 0.38 all
C8orf4 NKX2-1 4.54 0.38 all
LMO7 NKX2-1 4.58 0.38 all
PPP1R14A NKX2-1 4.60 0.38 all
LOC100132741 NKX2-1 4.59 0.38 all
FAM189A2 NKX2-1 4.58 0.38 all
STXBP6 EGR1 4.21 0.38 all
GPR20 NKX2-1 4.66 0.38 all
OGN NKX2-1 4.64 0.38 all
FLRT3 EGR1 4.13 0.38 all
TCF21 EGR1 4.23 0.38 all
SPON1 EGR1 4.19 0.38 all
ITGA1 EGR1 4.20 0.38 all
DENND2A NKX2-1 4.55 0.38 all
MYH11 NKX2-1 4.54 0.38 all
TMEM163 NKX2-1 4.66 0.38 all
ITGA8 EGR1 4.17 0.38 all
CH25H NKX2-1 4.38 0.37 all
OR7E47P NKX2-1 4.46 0.37 all
CHRDL1 EGR1 4.02 0.37 all
RHOBTB2 NKX2-1 4.41 0.37 all
TMTC2 NKX2-1 4.38 0.37 all
LOC100129069 NKX2-1 4.51 0.37 all
CYP4B1 EGR1 4.05 0.37 all
SPON1 NKX2-1 4.46 0.37 all
NOSTRIN NKX2-1 4.30 0.36 all
MAGI3 NKX2-1 4.32 0.36 all
CASS4 NKX2-1 4.24 0.36 all
SNED1 NKX2-1 4.22 0.36 all
EGR1 NKX2-1 4.24 0.36 all
GRK5 NKX2-1 4.31 0.36 all
STXBP6 NKX2-1 4.30 0.36 all
TEPP NKX2-1 4.31 0.36 all
C7 NKX2-1 4.27 0.36 all
CAPSL NKX2-1 4.21 0.36 all
FLJ30901 NKX2-1 4.31 0.36 all
PCDH20 NKX2-1 4.12 0.35 all
ACADL NKX2-1 4.08 0.35 all
AQP1 NKX2-1 4.10 0.35 all
ADAMTSL3 NKX2-1 4.13 0.35 all
RETN NKX2-1 4.13 0.35 all
TMEM186 NKX2-1 4.51 -0.37 all
HARS2 EGR1 4.56 -0.40 all
FGFR1OP TBX4 4.21 -0.42 all
FBXO45 TBX2 4.54 -0.43 all
FAM199X TBX4 4.54 -0.44 all
BRI3BP TBX4 4.73 -0.45 all
LOC100996388 FOXF1 4.13 -0.48 all
LOC100996388 TCF21 4.08 -0.48 all