Gene Regulatory Network

Homo Sapiens: endothelial_subnet_5

Gene Count Regulator Count Target Count Average Targets per TF Average TFs per Target
155 8 237 30.40 0.03

Top GO Annotations

organelle fission (1.03e-267), mitotic prometaphase (1.44e-232), cell division (5.9e-184), chromosome segregation (1.88e-168), regulation of cell cycle process (1.09e-147), sister chromatid segregation (4.07e-108), establishment of chromosome localization (2.68e-93), negative regulation of cell cycle (1.33e-86), chromosome condensation (1.62e-83), DNA replication (3.55e-83)

Tissue Types







GRN Members

TG TF Z-Score Correlation Tissue Type
MCM10 ORC1 7.44 0.89 all
MCM4 ORC1 7.23 0.88 all
UBE2C CDT1 8.43 0.88 all
CDC25A ORC1 7.14 0.88 all
CDC45 CDT1 8.43 0.88 all
RAD54L CDT1 8.13 0.87 all
EXO1 CDT1 8.08 0.87 all
KIF2C CDT1 8.21 0.87 all
CDCA5 CDT1 8.07 0.87 all
CDC6 ORC1 6.85 0.86 all
CDCA3 CDT1 7.98 0.86 all
TPX2 CDT1 7.88 0.86 all
KIF15 BRCA1 7.69 0.85 all
MND1 ORC1 6.72 0.85 all
MKI67 CDT1 7.79 0.85 all
PTTG1 CDT1 7.68 0.85 all
TK1 CDT1 7.61 0.84 all
KIF15 CDT1 7.52 0.84 all
DTL BRCA1 7.44 0.84 all
DTL CDT1 7.65 0.84 all
OIP5 BRCA1 7.53 0.84 all
BIRC5 CDT1 7.58 0.84 all
HJURP CDT1 7.53 0.84 all
NCAPH CDT1 7.37 0.83 all
FANCI CDT1 7.42 0.83 all
CENPF BRCA1 7.34 0.83 all
CDCA8 CDT1 7.32 0.83 all
GTSE1 CDT1 7.43 0.83 all
KIAA0101 CDT1 7.45 0.83 all
CDC45 BRCA1 7.11 0.82 all
MKI67 BRCA1 7.17 0.82 all
CDC25C CDT1 7.28 0.82 all
CDC25A BRCA1 6.98 0.81 all
FAM64A CDT1 7.02 0.81 all
PTTG3P BRCA1 6.73 0.80 all
KIF18B BRCA1 6.77 0.80 all
DEPDC1 BRCA1 6.76 0.80 all
POLE2 ORC1 6.01 0.80 all
ERCC6L BRCA1 6.81 0.80 all
SPC24 BRCA1 6.86 0.80 all
DEPDC1 CDT1 6.61 0.79 all
PLK1 CDT1 6.75 0.79 all
RNASEH2A BRCA1 6.50 0.78 all
RNASEH2A CDT1 6.49 0.78 all
GTSE1 BRCA1 6.52 0.78 all
KIF4A CDT1 6.32 0.77 all
SMC4 BRCA1 6.14 0.76 all
BUB1 CDT1 6.26 0.76 all
LMNB1 ORC1 5.47 0.76 all
RRM1 BRCA1 6.10 0.76 all
FANCI POLA1 7.76 0.75 all
RFC5 ORC1 5.37 0.75 all
BRCA2 ORC1 5.29 0.75 all
PRIM1 POLA1 7.80 0.75 all
NUP107 DEK 5.72 0.74 all
KIF15 POLA1 7.30 0.73 all
CACYBP DEK 4.73 0.73 non-blood
POLE2 POLA1 7.27 0.73 all
MCM10 POLA1 7.44 0.73 all
MND1 POLA1 7.46 0.73 all
ARL6IP6 DEK 5.46 0.72 all
WDHD1 POLA1 7.13 0.72 all
GINS1 POLA1 7.25 0.72 all
PLK4 POLA1 7.18 0.72 all
CDCA7 BRCA1 5.63 0.72 all
POLA1 DEK 4.66 0.72 non-blood
RFC2 BRCA1 5.54 0.72 all
RAD51AP1 POLA1 7.16 0.72 all
FAM64A BRCA1 5.50 0.72 all
PHF19 CDT1 5.51 0.71 all
KIF11 POLA1 6.93 0.71 all
WHSC1 BRCA1 5.43 0.71 all
BUB1B POLA1 6.99 0.71 all
RBL1 DEK 4.52 0.71 non-blood
DLGAP5 POLA1 6.90 0.71 all
CDC6 POLA1 6.89 0.71 all
NUF2 POLA1 7.02 0.71 all
DTL POLA1 6.93 0.71 all
OIP5 POLA1 6.93 0.71 all
TTK POLA1 6.95 0.71 all
SPC25 POLA1 7.07 0.71 all
CENPM BRCA1 5.38 0.71 all
OIP5 DEK 4.44 0.70 non-blood
GSTCD DEK 4.45 0.70 non-blood
SMC4 DEK 5.14 0.70 all
BRIP1 POLA1 6.84 0.70 all
RMI2 POLA1 6.87 0.70 all
HELLS POLA1 6.70 0.70 all
DEPDC1B POLA1 6.70 0.70 all
CKS1B POLA1 6.68 0.70 all
CCNB1 POLA1 6.84 0.70 all
PLK1 BRCA1 5.35 0.70 all
CCNE2 ORC1 4.74 0.70 all
CENPF POLA1 6.75 0.70 all
MLF1IP POLA1 6.49 0.69 all
MCM4 POLA1 6.67 0.69 all
UBE2C POLA1 6.53 0.69 all
MCM5 CDT1 5.17 0.69 all
EXO1 POLA1 6.60 0.69 all
MAD2L1 POLA1 6.60 0.69 all
CDC25A POLA1 6.55 0.69 all
KIF14 POLA1 6.53 0.69 all
CDK1 POLA1 6.68 0.69 all
HMMR POLA1 6.63 0.69 all
AUNIP POLA1 6.61 0.69 all
CENPE POLA1 6.66 0.69 all
RAD54L POLA1 6.42 0.68 all
KIF4A POLA1 6.39 0.68 all
BARD1 DEK 4.88 0.68 all
NEIL3 DEK 4.26 0.68 non-blood
TCF19 CDT1 5.13 0.68 all
KIF2C POLA1 6.46 0.68 all
NEK2 POLA1 6.32 0.68 all
FEN1 POLA1 6.37 0.68 all
RFC5 POLA1 6.32 0.68 all
NCAPG POLA1 6.46 0.68 all
CBX3 DEK 4.96 0.68 all
TPX2 POLA1 6.40 0.68 all
CCNA2 POLA1 6.48 0.68 all
CDCA5 POLA1 6.49 0.68 all
KIF20A POLA1 6.40 0.68 all
MAD2L1 DEK 4.13 0.67 non-blood
KIF18B POLA1 6.26 0.67 all
AHCTF1 DEK 4.18 0.67 non-blood
BARD1 POLA1 6.20 0.67 all
DEPDC1 POLA1 6.13 0.67 all
MND1 DEK 4.10 0.67 non-blood
BUB1 POLA1 6.21 0.67 all
KIF18A POLA1 6.14 0.67 all
BIRC5 POLA1 6.20 0.67 all
CDC45 POLA1 6.27 0.67 all
CENPA POLA1 6.13 0.67 all
RAD51AP1 DEK 4.86 0.67 all
TOP2A POLA1 6.18 0.67 all
NUSAP1 POLA1 6.28 0.67 all
TACC3 BRCA1 4.92 0.67 all
CDC25C POLA1 6.06 0.66 all
STIL DEK 4.68 0.66 all
CDC20 POLA1 6.12 0.66 all
RMI1 DEK 4.01 0.66 non-blood
STIL POLA1 6.07 0.66 all
PAQR3 DEK 4.09 0.66 non-blood
NCAPG2 DEK 4.06 0.66 non-blood
RNASEH2A POLA1 6.11 0.66 all
ERCC6L DEK 4.01 0.66 non-blood
ZWINT POLA1 6.09 0.66 all
NEIL3 POLA1 6.08 0.66 all
MCM10 DEK 4.05 0.66 non-blood
NCAPG2 POLA1 5.97 0.66 all
UNG DEK 4.03 0.66 non-blood
CDT1 POLA1 6.10 0.66 all
ERCC6L POLA1 6.12 0.66 all
WDHD1 DEK 4.03 0.66 non-blood
CENPH DEK 4.04 0.66 non-blood
RFC2 DEK 4.01 0.66 non-blood
TMEM194A DEK 4.06 0.66 non-blood
MKI67 POLA1 6.07 0.66 all
FIGNL1 DEK 4.07 0.66 non-blood
FBXO5 POLA1 5.94 0.65 all
RRM2 POLA1 5.82 0.65 all
TRIP13 POLA1 5.94 0.65 all
KNTC1 POLA1 5.81 0.65 all
ASPM POLA1 5.88 0.65 all
KIF20B POLA1 4.51 0.65 non-blood
CDCA7 POLA1 5.89 0.65 all
NUSAP1 DEK 4.60 0.65 all
HJURP POLA1 5.83 0.65 all
RBL1 POLA1 4.93 0.65 endoderm
TMEM48 POLA1 5.80 0.65 all
TMEM194A POLA1 4.55 0.65 non-blood
CACYBP POLA1 4.41 0.64 non-blood
PSRC1 POLA1 4.42 0.64 non-blood
HAUS6 POLA1 5.73 0.64 all
CKAP2L POLA1 5.64 0.64 all
CENPH POLA1 5.68 0.64 all
PRC1 POLA1 5.72 0.64 all
KIAA0101 POLA1 5.75 0.64 all
PTTG1 POLA1 5.53 0.63 all
FOXM1 POLA1 5.61 0.63 all
SAAL1 POLA1 5.48 0.63 all
CEP55 POLA1 5.47 0.63 all
FAM54A POLA1 5.51 0.63 all
C11orf82 POLA1 5.61 0.63 all
CDCA3 POLA1 5.47 0.63 all
HELLS DEK 4.41 0.63 all
PRIM1 DEK 4.41 0.63 all
KIAA1524 POLA1 5.54 0.63 all
NCAPH POLA1 5.33 0.62 all
POLE2 DEK 4.22 0.62 all
ECT2 POLA1 5.34 0.62 all
SKA1 POLA1 5.38 0.62 all
CDCA7 DEK 4.30 0.62 all
FIGNL1 POLA1 5.34 0.62 all
RRM1 POLA1 5.32 0.62 all
ZWILCH POLA1 5.27 0.61 all
DCLRE1B POLA1 4.05 0.61 non-blood
GSTCD POLA1 5.22 0.61 all
TCF19 POLA1 5.20 0.61 all
GINS3 POLA1 5.24 0.61 all
LOC100288637 POLA1 5.20 0.61 all
HMGB3P1 POLA1 4.01 0.60 non-blood
PTTG3P POLA1 5.10 0.60 all
TRMT5 POLA1 5.06 0.60 all
NCAPD2 POLA1 5.06 0.60 all
TIMELESS POLA1 5.16 0.60 all
RFC2 POLA1 5.03 0.60 all
HMGXB4 POLA1 4.04 0.60 non-blood
PHF19 BRCA1 4.17 0.60 all
TK1 POLA1 4.95 0.59 all
E2F7 POLA1 5.00 0.59 all
CDKN3 POLA1 4.91 0.59 all
CCNE2 POLA1 4.89 0.59 all
FAM64A POLA1 4.87 0.58 all
FANCG POLA1 4.86 0.58 all
C5orf34 POLA1 4.86 0.58 all
ARHGEF39 POLA1 4.78 0.58 all
CDCA8 POLA1 4.83 0.58 all
GTSE1 POLA1 4.78 0.58 all
SMC4 POLA1 4.73 0.57 all
WHSC1 POLA1 4.64 0.57 all
PRMT5 POLA1 4.62 0.57 all
BRCA2 POLA1 4.65 0.57 all
CENPL POLA1 4.59 0.56 all
HN1L POLA1 4.53 0.56 all
ZNF85 POLA1 4.60 0.56 all
EZH2 POLA1 4.54 0.56 all
PLK1 POLA1 4.58 0.56 all
TMPO POLA1 4.52 0.56 all
MCM5 POLA1 4.44 0.55 all
SUV39H1 POLA1 4.37 0.55 all
ANLN POLA1 4.30 0.54 all
TACC3 POLA1 4.11 0.52 all
EXOSC2 POLA1 4.08 0.52 all
SRPK1 POLA1 4.11 0.52 all
GABARAPL1 POLA1 4.59 -0.65 non-blood
JMJD8 DEK 4.02 -0.66 non-blood